| Hepatic lymphatic mapping: a pilot study for porta hepatis lymph node identification. | |
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MedLine Citation:
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PMID: 11338882 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The status of the porta hepatis lymph nodes in patients with hepatic metastases from colorectal cancer affects their prognosis and management. Lymphatic mapping with isosulfan blue dye is well established in breast cancer and melanoma. An animal model consisting of three dogs receiving general anesthesia was utilized. Each dog underwent a laparotomy and increasing doses of isosulfan blue dye were injected into the right medial segment of the liver. Intraoperatively, the presence of blue dye in the porta hepatis region was determined and the lymph node identified. Continuous physiological monitoring was performed. Serum determination of liver function tests, amylase levels, and white blood cell count were performed preoperatively and on postoperative days 1, 2, 4, and 7. The animals were sacrificed on day 7. A portal lymph node was identified in each case and there was no perioperative morbidity or mortality. There were no significant alterations in blood pressure or heart rate in the animals. There was a dose-responsive decrease in the O2 saturation as measured by transcutaneous monitoring, but arterial blood gas analysis showed that pO2 levels remained stable. There were no significant changes in the liver function tests, amylase levels, or white blood cell counts. There was a small increase in alkaline phosphatase, which normalized by postoperative day 7. Hepatic injection of isosulfan blue dye appears to be safe and effective in identifying porta hepatis lymph nodes in the animal model and sets the basis for further study in human subjects. |
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Authors:
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M S Kahlenberg; J M Kane; P M Kanter; T K Weber; J F Gibbs; M A Rodriguez-Bigas; N J Petrelli |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Cancer investigation Volume: 19 ISSN: 0735-7907 ISO Abbreviation: Cancer Invest. Publication Date: 2001 |
Date Detail:
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Created Date: 2001-05-07 Completed Date: 2001-05-17 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 8307154 Medline TA: Cancer Invest Country: United States |
Other Details:
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Languages: eng Pagination: 256-60 Citation Subset: IM |
Affiliation:
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Department of Surgery, Section of Oncology, University of Texas, Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78299-3900, USA. Kahlenberg@uthscsa.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Gas Analysis Colorectal Neoplasms / pathology* Disease Models, Animal Dogs Liver / drug effects, physiology Liver Neoplasms / diagnosis, secondary* Lymph Nodes / pathology* Lymphatic Metastasis Pilot Projects Portal Vein / pathology Prognosis Rosaniline Dyes / adverse effects, diagnostic use* |
| Chemical | |
Reg. No./Substance:
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0/Rosaniline Dyes; 68238-36-8/iso-sulfan blue |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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