Document Detail


Hepatic lymphatic mapping: a pilot study for porta hepatis lymph node identification.
MedLine Citation:
PMID:  11338882     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The status of the porta hepatis lymph nodes in patients with hepatic metastases from colorectal cancer affects their prognosis and management. Lymphatic mapping with isosulfan blue dye is well established in breast cancer and melanoma. An animal model consisting of three dogs receiving general anesthesia was utilized. Each dog underwent a laparotomy and increasing doses of isosulfan blue dye were injected into the right medial segment of the liver. Intraoperatively, the presence of blue dye in the porta hepatis region was determined and the lymph node identified. Continuous physiological monitoring was performed. Serum determination of liver function tests, amylase levels, and white blood cell count were performed preoperatively and on postoperative days 1, 2, 4, and 7. The animals were sacrificed on day 7. A portal lymph node was identified in each case and there was no perioperative morbidity or mortality. There were no significant alterations in blood pressure or heart rate in the animals. There was a dose-responsive decrease in the O2 saturation as measured by transcutaneous monitoring, but arterial blood gas analysis showed that pO2 levels remained stable. There were no significant changes in the liver function tests, amylase levels, or white blood cell counts. There was a small increase in alkaline phosphatase, which normalized by postoperative day 7. Hepatic injection of isosulfan blue dye appears to be safe and effective in identifying porta hepatis lymph nodes in the animal model and sets the basis for further study in human subjects.
Authors:
M S Kahlenberg; J M Kane; P M Kanter; T K Weber; J F Gibbs; M A Rodriguez-Bigas; N J Petrelli
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Cancer investigation     Volume:  19     ISSN:  0735-7907     ISO Abbreviation:  Cancer Invest.     Publication Date:  2001  
Date Detail:
Created Date:  2001-05-07     Completed Date:  2001-05-17     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  8307154     Medline TA:  Cancer Invest     Country:  United States    
Other Details:
Languages:  eng     Pagination:  256-60     Citation Subset:  IM    
Affiliation:
Department of Surgery, Section of Oncology, University of Texas, Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78299-3900, USA. Kahlenberg@uthscsa.edu
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MeSH Terms
Descriptor/Qualifier:
Animals
Blood Gas Analysis
Colorectal Neoplasms / pathology*
Disease Models, Animal
Dogs
Liver / drug effects,  physiology
Liver Neoplasms / diagnosis,  secondary*
Lymph Nodes / pathology*
Lymphatic Metastasis
Pilot Projects
Portal Vein / pathology
Prognosis
Rosaniline Dyes / adverse effects,  diagnostic use*
Chemical
Reg. No./Substance:
0/Rosaniline Dyes; 68238-36-8/iso-sulfan blue

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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