Document Detail


Hepatic lipogenic enzyme expression in pigs is affected by selection for decreased backfat thickness at constant intramuscular fat content.
MedLine Citation:
PMID:  23261534     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
This study investigated (i) whether genetic selection for decreased backfat thickness at constant intramuscular fat (IMF) affects the expression of lipogenic enzymes in pig liver and (ii) whether expression of the hepatic lipogenic enzymes is related to subcutaneous fat and IMF fatty acid composition. The enzymes investigated were fatty acid synthase (FAS), stearoyl-CoA desaturase and Δ6-desaturase (Δ6d). Experiments were conducted on 30 barrows (15 controls and 15 selected). Selected pigs had lower backfat thickness, which was accompanied by a reduced expression of the hepatic FAS and Δ6d when compared to control pigs. There was a trend towards a positive relationship between FAS and Δ6d protein expression and saturated and polyunsaturated fatty acids content respectively, in subcutaneous fat but not in muscle. It was concluded that selection against backfat thickness is associated with changes in expression of the hepatic FAS and Δ6d proteins. The changes in protein expression did not influence significantly the tissue fatty acid composition under these conditions.
Authors:
R Muñoz; J Estany; M Tor; O Doran
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-11-29
Journal Detail:
Title:  Meat science     Volume:  93     ISSN:  1873-4138     ISO Abbreviation:  Meat Sci.     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-12-24     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101160862     Medline TA:  Meat Sci     Country:  -    
Other Details:
Languages:  ENG     Pagination:  746-751     Citation Subset:  -    
Copyright Information:
Copyright © 2012 Elsevier Ltd. All rights reserved.
Affiliation:
Departament de Producció Animal, Universitat de Lleida, 191 Rovira Roure, 25198 Lleida, Spain.
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