Document Detail

Hepatic lipogenesis and ketogenesis in the mother and fetus during postmaturity in the rat.
MedLine Citation:
PMID:  6643953     Owner:  NLM     Status:  MEDLINE    
Prolongation of pregnancy for 1.5 days by the injection of progesterone leads to a decrease in maternal liver glycogen content and an increase in blood ketones without alteration in the activity of hepatic hydroxymethylglutaryl-CoA synthase, an enzyme of ketogenesis. Fetal hepatic mitochondrial hydroxymethylglutaryl-CoA synthase activity increases with increasing postmaturity in a similar manner to that observed in normal neonates, suggesting that the factors necessary for enzyme induction are present in utero during postmaturity and that birth and the intake of the milk diet of suckling are not essential for increased enzyme activity. Hepatic in vivo lipogenesis is elevated in both mother and fetus during prolonged pregnancy and the results indicate that progesterone may have a specific effect on hepatic lipogenesis.
A M Caswell; F C Higham; E Bailey
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of developmental physiology     Volume:  5     ISSN:  0141-9846     ISO Abbreviation:  J. Dev. Physiol.     Publication Date:  1983 Oct 
Date Detail:
Created Date:  1984-01-27     Completed Date:  1984-01-27     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  7910737     Medline TA:  J Dev Physiol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  299-305     Citation Subset:  IM    
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MeSH Terms
Fetus / metabolism*
Ketones / metabolism*
Lipid Metabolism*
Liver / metabolism*
Liver Glycogen / metabolism
Pregnancy, Prolonged*
Rats, Inbred Strains
Reg. No./Substance:
0/Ketones; 0/Liver Glycogen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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