| Hepatic left lobe volume is a sensitive index of metabolic improvement in obese women after gastric banding. | |
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MedLine Citation:
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PMID: 22143620 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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BACKGROUND:Nonalcoholic fatty liver disease is a common finding in obese subjects. Increasing evidence has been provided suggesting that it represents the hepatic component of the metabolic syndrome.OBJECTIVE:Aim of this longitudinal study was to evaluate the relationships between several anthropometric measures, including the hepatic left lobe volume (HLLV), and various indicators of the metabolic syndrome in a cohort of severely obese women before and after laparoscopic adjustable gastric banding (LAGB).STUDY DESIGN AND RESULTS:Seventy-five obese women (mean age 45±10 years and body mass index (BMI) 42.5±4.8 kg m(-2)) underwent LAGB and completed an average (±s.d.) post-surgical follow-up of 24±6 months. Determination of HLLV, subcutaneous and intra-abdominal fat (IAF) was based on ultrasound. The principal component statistical analysis applied to pre-operative measurements, highlighted HLLV as a parameter that clustered with serum insulin, IAF, serum glucose and uric acid, along with triglycerides (TGs), alkaline phosphatase and high-density lipoprotein cholesterol. After LAGB, the average reduction of BMI was 23%, 12% for subcutaneous fat (SCF), 42% for HLLV and 40% for visceral fat. Among body weight, BMI, SCF, IAF and HLLV, reduction of the latter was an independent predictor of reduction of serum transaminases and γ-Glutamyltransferase, glucose, insulin and TGs.CONCLUSIONS:In severely obese women: (i) HLLV is a sensitive indicator of ectopic fat deposition, clustering with parameters defining the metabolic syndrome; (ii) weight loss achieved by LAGB is associated with a reduction of liver volume as estimated by HLLV; (iii) among various anthropometric parameters measured, reduction of HLLV that follows LAGB represents the best single predictor of improvement of various cardiometabolic risk factors.International Journal of Obesity advance online publication, 6 December 2011; doi:10.1038/ijo.2011.243. |
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Authors:
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M Giannetti; P Piaggi; G Ceccarini; S Mazzeo; G Querci; P Fierabracci; G Salvetti; G Galli; I Ricco; S Martinelli; C Di Salvo; M Anselmino; A Landi; P Vitti; A Pinchera; F Santini |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-12-06 |
Journal Detail:
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Title: International journal of obesity (2005) Volume: - ISSN: 1476-5497 ISO Abbreviation: - Publication Date: 2011 Dec |
Date Detail:
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Created Date: 2011-12-6 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101256108 Medline TA: Int J Obes (Lond) Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of Endocrinology and Kidney, University Hospital of Pisa, Pisa, Italy. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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