| Hepatic lactate uptake versus leg lactate output during exercise in humans. | |
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MedLine Citation:
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PMID: 17656631 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The exponential rise in blood lactate with exercise intensity may be influenced by hepatic lactate uptake. We compared muscle-derived lactate to the hepatic elimination during 2 h prolonged cycling (62 +/- 4% of maximal O(2) uptake, (.)Vo(2max)) followed by incremental exercise in seven healthy men. Hepatic blood flow was assessed by indocyanine green dye elimination and leg blood flow by thermodilution. During prolonged exercise, the hepatic glucose output was lower than the leg glucose uptake (3.8 +/- 0.5 vs. 6.5 +/- 0.6 mmol/min; mean +/- SE) and at an arterial lactate of 2.0 +/- 0.2 mM, the leg lactate output of 3.0 +/- 1.8 mmol/min was about fourfold higher than the hepatic lactate uptake (0.7 +/- 0.3 mmol/min). During incremental exercise, the hepatic glucose output was about one-third of the leg glucose uptake (2.0 +/- 0.4 vs. 6.2 +/- 1.3 mmol/min) and the arterial lactate reached 6.0 +/- 1.1 mM because the leg lactate output of 8.9 +/- 2.7 mmol/min was markedly higher than the lactate taken up by the liver (1.1 +/- 0.6 mmol/min). Compared with prolonged exercise, the hepatic lactate uptake increased during incremental exercise, but the relative hepatic lactate uptake decreased to about one-tenth of the lactate released by the legs. This drop in relative hepatic lactate extraction may contribute to the increase in arterial lactate during intense exercise. |
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Authors:
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H B Nielsen; M A Febbraio; P Ott; P Krustrup; N H Secher |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2007-07-26 |
Journal Detail:
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Title: Journal of applied physiology (Bethesda, Md. : 1985) Volume: 103 ISSN: 8750-7587 ISO Abbreviation: J. Appl. Physiol. Publication Date: 2007 Oct |
Date Detail:
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Created Date: 2007-10-05 Completed Date: 2007-12-06 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8502536 Medline TA: J Appl Physiol Country: United States |
Other Details:
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Languages: eng Pagination: 1227-33 Citation Subset: IM |
Affiliation:
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Department of Anesthesia 2041, Rigshospitalet, Blegdamsvej 9, 2100 København Ø, Denmark. hbay@vip.cybercity.dk |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Blood Gas Analysis Exercise / physiology* Exercise Test Glucose / metabolism Hemodynamics / physiology Humans Lactic Acid / metabolism* Leg / blood supply Liver / blood supply, metabolism* Male Muscle, Skeletal / metabolism* Oxygen Consumption / physiology Regional Blood Flow / physiology |
| Chemical | |
Reg. No./Substance:
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50-21-5/Lactic Acid; 50-99-7/Glucose |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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