| Hepatic inactivation of gastrins of various chain lengths in dogs. | |
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MedLine Citation:
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PMID: 631485 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In dogs with gastric fistulae and with transposition of the portal vein and the inferior vena cava, we studied secretion of acid in response to portal or systemic venous infusion of a series of progressively longer fragments of the carboxyl terminal portion of human gastrin. Pentagastrin, G6, G7, G8, G9, G10, G13, G17, and G34 were studied. Potency by portal venous infusion relative to systemic venous infusion was used as an index of hepatic inactivation. Fragments with eight or fewer amino acid residues were more than 90% inactivated by hepatic transit. Fragments with nine or more amino acid residues were more resistant to hepatic inactivation than shorter fragments. For fragments with 7 to 17 amino acid residues, increasing the chain length was accompanied by progressive increase both in hepatic resistance to inactivation and in potency for stimulation of acid secretion, suggesting that resistance to hepatic inactivation may be a major determinant of potency. |
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Authors:
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U T Strunz; M R Thompson; J Elashoff; M I Grossman |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Gastroenterology Volume: 74 ISSN: 0016-5085 ISO Abbreviation: Gastroenterology Publication Date: 1978 Mar |
Date Detail:
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Created Date: 1978-05-24 Completed Date: 1978-05-24 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0374630 Medline TA: Gastroenterology Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 550-3 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Dogs Gastric Juice / metabolism Gastrins / administration & dosage, blood, pharmacology* Infusions, Parenteral Liver / metabolism* Pentagastrin / pharmacology Portal System |
| Chemical | |
Reg. No./Substance:
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0/Gastrins; 5534-95-2/Pentagastrin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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