| Hepatic histidase gene expression responds to protein rehabilitation in undernourished growing rats. | |
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MedLine Citation:
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PMID: 9772128 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We studied the effect of nutritional rehabilitation with a 6, 18 or 50% casein diet in undernourished rats on histidase (Hal) expression. Undernutrition was induced by feeding rats a 0.5% casein diet for 5 wk. Over this period, growth, serum total proteins and insulin-like growth factor-I (IGF-I) levels were significantly lower than those of rats that freely consumed an 18% casein diet. During this period, undernutrition also significantly reduced Hal activity and Hal-mRNA concentration. Nutritional rehabilitation for 21 d with a 6% casein diet did not change any of these variables. Nutritional rehabilitation with an 18 or 50% casein diet for 1 d initiated the restoration of Hal activity and mRNA concentration. After 10 d of consuming 18 or 50% casein diets, Hal activity was 5- and 14-fold, and mRNA concentration was 8.5- and 23-fold higher, respectively, than in the protein-undernourished group (PU). During this period, body weight, total serum proteins and IGF-I levels were also significantly (P < 0.05) higher than those of the PU group. At the end of 21 d of rehabilitation with an 18 or 50% casein diet, Hal activity was 14- and 31-fold higher and Hal mRNA concentration was 10- and 24-fold higher, respectively, than in the PU group. In conclusion, our data showed that rehabilitation of undernourished rats with a 6% casein diet was not sufficient to re-establish growth indicators, Hal activity or gene expression, and that nutritional rehabilitation with an 18 or 50% casein diet effectively re-established body weight , biochemical variables and the capacity of histidase gene expression to eliminate the excess of protein. |
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Authors:
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A R Tovar; A Santos; A Halhali; H Bourges; N Torres |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The Journal of nutrition Volume: 128 ISSN: 0022-3166 ISO Abbreviation: J. Nutr. Publication Date: 1998 Oct |
Date Detail:
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Created Date: 1998-11-13 Completed Date: 1998-11-13 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0404243 Medline TA: J Nutr Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1631-5 Citation Subset: IM |
Affiliation:
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Departamento de Fisiología de la Nutrición, Instituto Nacional de la Nutrición,"Salvador Zubirán" México, D.F. México, 14000, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Analysis of Variance Animals Blood Proteins / metabolism Body Weight / drug effects Caseins / administration & dosage Dietary Proteins / therapeutic use* Gene Expression Regulation, Enzymologic* Histidine Ammonia-Lyase / genetics*, metabolism* Insulin-Like Growth Factor I / metabolism Liver / drug effects, metabolism Male Organ Size / drug effects Protein-Energy Malnutrition / diet therapy*, enzymology, rehabilitation Rats Rats, Wistar |
| Chemical | |
Reg. No./Substance:
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0/Blood Proteins; 0/Caseins; 0/Dietary Proteins; 67763-96-6/Insulin-Like Growth Factor I; EC 4.3.1.3/Histidine Ammonia-Lyase |
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