| Hepatic heterogeneity in the response to AMP studies in the bivascularly perfused rat liver. | |
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MedLine Citation:
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PMID: 9584983 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The zonation of the purinergic action of AMP in the hepatic parenchyma was investigated in the bivascularly perfused rat liver by means of anterograde and retrograde perfusion. Livers from fed rats were used and AMP (100 microM) was infused according to four different experimental protocols: (A) anterograde perfusion and AMP infusion via the portal vein; (B) anterograde perfusion and AMP infusion via the hepatic artery; (C) retrograde perfusion and AMP via the hepatic vein; (D) retrograde perfusion and AMP via the hepatic artery. The response of the liver cells was heterogeneous. Oxygen uptake inhibition by AMP predominates in cells situated shortly after the intrasinusoidal confluence of the portal vein and hepatic artery. Oxygen consumption in all other cells seems to be increased by AMP. Glycogenolysis stimulation by AMP (glucose release) was more pronounced in the periportal cells situated in the region of the intrasinusoidal confluence of the portal vein and the hepatic artery. It can be concluded that the heterogenic response of the liver to AMP is similar to the heterogenic response to ATP. |
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Authors:
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V C Minguetti-Câmara; J Constantin; F Suzuki-Kemmelmeier; A Bracht |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Biochemistry and molecular biology international Volume: 44 ISSN: 1039-9712 ISO Abbreviation: Biochem. Mol. Biol. Int. Publication Date: 1998 Apr |
Date Detail:
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Created Date: 1998-06-12 Completed Date: 1998-06-12 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9306673 Medline TA: Biochem Mol Biol Int Country: AUSTRALIA |
Other Details:
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Languages: eng Pagination: 693-702 Citation Subset: IM |
Affiliation:
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Laboratory of Liver Metabolism, University of Maringá, Brazil. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adenosine Monophosphate
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administration & dosage,
pharmacology* Animals Glucose / metabolism, secretion Hepatic Artery Liver / blood supply, drug effects*, metabolism* Liver Glycogen / metabolism Male Oxygen / metabolism Oxygen Consumption / drug effects Perfusion / methods Portal Vein Rats Rats, Wistar |
| Chemical | |
Reg. No./Substance:
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0/Liver Glycogen; 50-99-7/Glucose; 61-19-8/Adenosine Monophosphate; 7782-44-7/Oxygen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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