Document Detail


Hepatic and haematological adverse reactions associated with the use of multidrug therapy in leprosy--a five year retrospective study.
MedLine Citation:
PMID:  11579648     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This study analyses retrospectively some of the risks associated with the use of WHO-multidrug therapy (MDT) in Sri Lanka. Case records of 3,333 new cases of leprosy attending the Central Leprosy Clinic in Colombo during 1991-1995, were analysed for adverse drug reactions involving the liver and blood. There were 81 reports of suspected hepatic or haematological adverse reactions associated with the use of MDT, of which 39 were classified as haemolytic anaemia, 25 as toxic hepatitis, 2 as methaemoglobinaemia and 15 as anaemia. Dapsone, was incriminated in the majority of adverse reactions (72%). Adverse drug reactions were more common in female than male subjects (55% vs 45%; P < 0.5), but there was no significant differences between the age groups. Majority of adverse reactions was seen within the first three months of initiation of MDT. This study in no way undermines the benefits of MDT but highlights the risks and suggests measures to minimize these risks.
Authors:
S I Kaluarachchi; B M Fernandopulle; B P Gunawardane
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Indian journal of leprosy     Volume:  73     ISSN:  0254-9395     ISO Abbreviation:  Indian J Lepr     Publication Date:    2001 Apr-Jun
Date Detail:
Created Date:  2001-10-02     Completed Date:  2002-02-21     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  8409173     Medline TA:  Indian J Lepr     Country:  India    
Other Details:
Languages:  eng     Pagination:  121-9     Citation Subset:  IM    
Affiliation:
National Drug Quality Assurance Laboratory, Norris Canal Road, Colombo 10, Sri Lanka.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Anemia / chemically induced,  epidemiology*
Child
Clofazimine / adverse effects
Dapsone / adverse effects
Drug Therapy, Combination
Drug-Induced Liver Injury / epidemiology*
Female
Humans
Leprostatic Agents / adverse effects*,  therapeutic use
Leprosy / drug therapy*
Male
Methemoglobinemia / chemically induced,  epidemiology*
Middle Aged
Retrospective Studies
Rifampin / adverse effects,  therapeutic use
Chemical
Reg. No./Substance:
0/Leprostatic Agents; 13292-46-1/Rifampin; 2030-63-9/Clofazimine; 80-08-0/Dapsone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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