Document Detail

Hepatic fat during fasting and refeeding by MRI fat quantification.
MedLine Citation:
PMID:  24590550     Owner:  NLM     Status:  Publisher    
PURPOSE: To explore the sensitivity of high-field small animal magnetic resonance imaging to dynamic changes in fat content in the liver and to characterize the effect of prandial state on imaging studies of hepatic fat.
MATERIALS AND METHODS: A total of three timepoints were acquired using asymmetric spin-echo acquisitions for 12 mice with 24-hour spacing. After the first scan, half of the cohort was placed on a water-only diet. The second half of the cohort continued to have access to their high-fat chow. The scans were repeated after 24 hours. All animals were then returned to the high-fat diet, and the scans were again repeated after 24 hours. Fat fraction maps were computed using previously described methods. Regions of interests were manually drawn in the livers and the patterns of the two groups over time were compared.
RESULTS: Five out of six of the animals in the starved group showed an increase in hepatic fat fraction during the fasting period (average increase 0.54 ± 0.48), which decreased on refeeding. Analysis of variance indicated that the results significantly depended on both the group and the timepoint (P = 0.003).
CONCLUSION: Fat-water imaging methods are able to measure hepatic fat changes caused by short-term dietary perturbations.J. Magn. Reson. Imaging 2014. © 2014 Wiley Periodicals, Inc.
Sreenath Narayan; Chris A Flask; Satish C Kalhan; David L Wilson
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-3-3
Journal Detail:
Title:  Journal of magnetic resonance imaging : JMRI     Volume:  -     ISSN:  1522-2586     ISO Abbreviation:  J Magn Reson Imaging     Publication Date:  2014 Mar 
Date Detail:
Created Date:  2014-3-4     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9105850     Medline TA:  J Magn Reson Imaging     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2014 Wiley Periodicals, Inc.
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