| Hepatic ethanol elimination kinetics in patients with cirrhosis. | |
| | |
MedLine Citation:
|
PMID: 19404864 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVE: To address the question of whether increased ethanol elimination in alcoholics can be ascribed to increased metabolism via alcohol dehydrogenase (ADH; K(m) around 0.2 mM) or the microsomal ethanol-oxidizing system (MEOS; K(m) 10 mM) by kinetic analysis of hepatic ethanol elimination in recently drinking patients with alcoholic cirrhosis and healthy subjects. A further objective was to investigate whether systemic clearance of ethanol at low arterial ethanol concentrations can be used as a measure of hepatic blood flow. MATERIAL AND METHODS: Six patients with alcoholic cirrhosis were enrolled after 2 days of abstinence, along with 6 healthy subjects. Ethanol was administered as 6 successive infusions in increasing doses. Arterial and hepatic venous blood concentrations of ethanol were measured; hepatic blood flow was measured simultaneously. Kinetic parameters were calculated according to the sinusoidal perfusion model of enzymatic elimination by the intact liver. RESULTS: Mean hepatic K(m) for ethanol was 0.16 mM (range 0.09-0.36) in healthy subjects and 0.36 mM (range 0.16-0.69) in patients with cirrhosis (p>0.3), both compatible with the K(m) for ADH. The two groups of subjects had similar V(max) values (p>0.3). Extrahepatic elimination of ethanol accounted for more than 50% of total elimination in both groups, which precludes the use of systemic clearance as a measure of hepatic blood flow. CONCLUSIONS: The results support the hypothesis that ADH remains the main pathway for hepatic elimination of ethanol in recently drinking patients with alcoholic cirrhosis. We interpret this as evidence against a significant contribution of MEOS in vivo. |
| | |
Authors:
|
Gitte Dam; Michael Sørensen; Ole Lajord Munk; Susanne Keiding |
Related Documents
:
|
3065164 - Abnormally high alcohol concentration in the heart blood. 7231284 - Use of an alcometer in a casualty department. 1297784 - Blood levels and urinary excretion of thiamin and riboflavin during oral administration... 8907414 - Kinetics of n-butyl alcohol and m-xylene in blood during single and combined inhalation... 3573764 - Computer analysis of portal hemodynamics after small-diameter portacaval h-grafts: the ... 10382594 - A new minimally invasive technique to show nerve ischaemia in diabetic neuropathy. |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Scandinavian journal of gastroenterology Volume: 44 ISSN: 1502-7708 ISO Abbreviation: Scand. J. Gastroenterol. Publication Date: 2009 |
Date Detail:
|
Created Date: 2009-11-20 Completed Date: 2010-02-25 Revised Date: 2011-09-26 |
Medline Journal Info:
|
Nlm Unique ID: 0060105 Medline TA: Scand J Gastroenterol Country: England |
Other Details:
|
Languages: eng Pagination: 867-71 Citation Subset: IM |
Affiliation:
|
Department of Medicine V (Hepatology), Aarhus University Hospital, Aarhus, Denmark. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Aged Alcohol Oxidoreductases / metabolism* Case-Control Studies Contrast Media Cytochrome P-450 Enzyme System / metabolism* Ethanol / pharmacokinetics* Female Humans Iohexol Liver Cirrhosis, Alcoholic / metabolism* Male Middle Aged |
| Grant Support | |
ID/Acronym/Agency:
|
1 R01 DK-074419/DK/NIDDK NIH HHS; R01 DK074419-02/DK/NIDDK NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Contrast Media; 64-17-5/Ethanol; 66108-95-0/Iohexol; 9035-51-2/Cytochrome P-450 Enzyme System; EC 1.1.-/Alcohol Oxidoreductases; EC 1.1.1.-/microsomal ethanol-oxidizing system |
| Comments/Corrections | |
Comment In:
|
Scand J Gastroenterol. 2010 Mar;45(3):382-3; author reply 384
[PMID:
19900053
]
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Paradoxical effect of Klebsiella pneumoniae OmpK36 porin deficiency.
Next Document: Erectile dysfunction after prostatectomy: an evaluation of the risk factors.