| Hepatic endopolyploidy as a cellular consequence of age-specific selection for rate of development in mice. | |
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MedLine Citation:
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PMID: 18247336 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Endopolyploidy is the generation of polyploid cells by DNA replication without subsequent cell division and is correlated with hypertrophic growth or growth via cell size. Thus, selection that alters growth may also change onset and frequency of endopolyploidy as a correlated response. We search for endopolyploidy in the liver in response to age-specific restricted index selection for the rate of development. Polyploidy changes over ontogeny are described in five mouse lines: two selected for divergence in early growth (0-10 days of age), two selected for divergence in late growth (28-56 days of age), and one randombred control. Polyploid cell frequency within each line increased as ontogeny continued, as expected from previous research. However, selection for altered growth clearly plays a role in the frequency and onset of polyploid cells. Lines selected for divergence in early growth have polyploidy differences after weaning that are not seen in adult mice. However, lines selected for divergence in late growth are divergent in frequency of polyploid cells, starting near sexual maturity and continuing into adulthood. |
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Authors:
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Jhondra Funk-Keenan; Frances Haire; Sara Woolard; William R Atchley |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural |
Journal Detail:
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Title: Journal of experimental zoology. Part B, Molecular and developmental evolution Volume: 310 ISSN: 1552-5015 ISO Abbreviation: J. Exp. Zool. B Mol. Dev. Evol. Publication Date: 2008 Jul |
Date Detail:
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Created Date: 2008-06-23 Completed Date: 2008-08-11 Revised Date: 2009-10-05 |
Medline Journal Info:
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Nlm Unique ID: 101168228 Medline TA: J Exp Zool B Mol Dev Evol Country: United States |
Other Details:
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Languages: eng Pagination: 385-97 Citation Subset: IM |
Copyright Information:
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Copyright 2008 Wiley-Liss, Inc. |
Affiliation:
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Department of Genetics, North Carolina State University, Raleigh, North Carolina, USA. funkkeenan@wisc.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aging
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genetics,
pathology* Animals Female Flow Cytometry Growth* Liver / metabolism, pathology* Male Mice Mice, Inbred ICR Polyploidy* |
| Grant Support | |
ID/Acronym/Agency:
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GM045344/GM/NIGMS NIH HHS; GM08443/GM/NIGMS NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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