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Hepatic encephalopathy after treatment with temozolomide.
MedLine Citation:
PMID:  20730617     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Temozolomide in combination with radiation has been in use for more than 5 years for the therapy of glioblastoma. Known adverse effects concerning the gastrointestinal system are elevation of liver enzymes. We present the case of a patient treated with temozolomide who developed severe cholestatic liver damage and consecutive hepatic encephalopathy. Neurological symptoms were mistaken as being caused by focal brain damage for more than 9 months. After the correct diagnosis had been made and the treatment had been started, the patient's condition ameliorated. In conclusion, neurological deficits in patients with known brain lesion should not be attributed automatically to the pre-existing damage even if it is progressive but should be examined carefully, also including toxic and metabolic encephalopathies into the differential diagnosis. Furthermore, new side effects of drugs have to be considered. At least this case might lead to a closer monitoring of liver enzymes during temozolomide therapy.
Authors:
Annemarie Goldbecker; Anita Blanka Tryc; Peter Raab; Hans Worthmann; Julian Herrmann; Karin Weissenborn
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Publication Detail:
Type:  Journal Article     Date:  2010-08-22
Journal Detail:
Title:  Journal of neuro-oncology     Volume:  103     ISSN:  1573-7373     ISO Abbreviation:  J. Neurooncol.     Publication Date:  2011 May 
Date Detail:
Created Date:  2011-05-09     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8309335     Medline TA:  J Neurooncol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  163-6     Citation Subset:  IM    
Affiliation:
Department of Neurology and Clinical Neurophysiology, Hannover Medical School, 30623, Hannover, Germany, goldbecker.annemarie@mh-hannover.de.
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