| Hepatic disease in patients with the acquired immune deficiency syndrome (AIDS). | |
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MedLine Citation:
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PMID: 2820858 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The spectrum of liver disease in patients with acquired immune deficiency syndrome (AIDS) and the clinical impact of diagnostic percutaneous liver biopsy in this population were evaluated by a retrospective review of hepatic histology, clinical features and laboratory data in 85 patients (26 biopsies, 59 autopsies). Only 1 (3.8%) biopsy and 9 (15%) postmortem livers were histologically normal. Macrosteatosis and nonspecific portal inflammation were the most common histologic abnormalities. Intrahepatic AIDS-specific opportunistic infections or malignancies were detected in 42% of both biopsy and autopsy groups, with Mycobacterium avium-intracellulare the most frequent pathogen seen. Kaposi's sarcoma, although not detected on biopsy, was the most common postmortem AIDS-related hepatic finding. Intrahepatic lymphoma, cytomegalovirus hepatitis and hepatic mycoses were less frequently observed. In general, hepatic involvement represented part of a previously diagnosed, widely disseminated disease process, and liver biopsy led to new AIDS-specific diagnoses in only two patients. We conclude that while liver biopsy is a useful diagnostic tool in selected patients with AIDS, the information provided by biopsy rarely influences therapy or leads to improved survival. |
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Authors:
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D J Schneiderman; D M Arenson; J P Cello; W Margaretten; T E Weber |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Hepatology (Baltimore, Md.) Volume: 7 ISSN: 0270-9139 ISO Abbreviation: Hepatology Publication Date: 1987 Sep-Oct |
Date Detail:
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Created Date: 1987-11-02 Completed Date: 1987-11-02 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 8302946 Medline TA: Hepatology Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 925-30 Citation Subset: IM; X |
Affiliation:
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Medicine Service, San Francisco General Hospital, California. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acquired Immunodeficiency Syndrome
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complications* Adult Autopsy Biopsy Cytomegalovirus Infections / etiology Female Humans Liver / pathology Liver Diseases / diagnosis, etiology*, pathology Liver Function Tests Liver Neoplasms / etiology, pathology Male Mycobacterium Infections / etiology Mycobacterium avium Retrospective Studies Sarcoma, Kaposi / etiology, pathology |
| Grant Support | |
ID/Acronym/Agency:
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AM 07007/AM/NIADDK NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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