Document Detail


Hepatic disease in patients with the acquired immune deficiency syndrome (AIDS).
MedLine Citation:
PMID:  2820858     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The spectrum of liver disease in patients with acquired immune deficiency syndrome (AIDS) and the clinical impact of diagnostic percutaneous liver biopsy in this population were evaluated by a retrospective review of hepatic histology, clinical features and laboratory data in 85 patients (26 biopsies, 59 autopsies). Only 1 (3.8%) biopsy and 9 (15%) postmortem livers were histologically normal. Macrosteatosis and nonspecific portal inflammation were the most common histologic abnormalities. Intrahepatic AIDS-specific opportunistic infections or malignancies were detected in 42% of both biopsy and autopsy groups, with Mycobacterium avium-intracellulare the most frequent pathogen seen. Kaposi's sarcoma, although not detected on biopsy, was the most common postmortem AIDS-related hepatic finding. Intrahepatic lymphoma, cytomegalovirus hepatitis and hepatic mycoses were less frequently observed. In general, hepatic involvement represented part of a previously diagnosed, widely disseminated disease process, and liver biopsy led to new AIDS-specific diagnoses in only two patients. We conclude that while liver biopsy is a useful diagnostic tool in selected patients with AIDS, the information provided by biopsy rarely influences therapy or leads to improved survival.
Authors:
D J Schneiderman; D M Arenson; J P Cello; W Margaretten; T E Weber
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Hepatology (Baltimore, Md.)     Volume:  7     ISSN:  0270-9139     ISO Abbreviation:  Hepatology     Publication Date:    1987 Sep-Oct
Date Detail:
Created Date:  1987-11-02     Completed Date:  1987-11-02     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8302946     Medline TA:  Hepatology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  925-30     Citation Subset:  IM; X    
Affiliation:
Medicine Service, San Francisco General Hospital, California.
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MeSH Terms
Descriptor/Qualifier:
Acquired Immunodeficiency Syndrome / complications*
Adult
Autopsy
Biopsy
Cytomegalovirus Infections / etiology
Female
Humans
Liver / pathology
Liver Diseases / diagnosis,  etiology*,  pathology
Liver Function Tests
Liver Neoplasms / etiology,  pathology
Male
Mycobacterium Infections / etiology
Mycobacterium avium
Retrospective Studies
Sarcoma, Kaposi / etiology,  pathology
Grant Support
ID/Acronym/Agency:
AM 07007/AM/NIADDK NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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