| Hepatic complications of hematopoietic cell transplantation. | |
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MedLine Citation:
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PMID: 17335679 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Acute and chronic liver disease contributes significantly to morbidity and mortality following hematopoietic cell transplantation (HCT). The best prognostic indicator for the development of severe liver dysfunction is an early rise in liver function test results after HCT. The leading causes soon after HCT are acute graft-versus-host disease (GVHD), sinusoidal obstruction syndrome, drug and total parenteral nutrition hepatotoxicity, sepsis, and viral infection. Hepatic herpesvirus and fungal infections after HCT, though uncommon, can be life-threatening and warrant immediate diagnosis and treatment. Hepatitis B, hepatitis C virus, iron overload, and chronic GVHD are among the most common causes for chronic liver disease after HCT. Because treatments are directed at the underlying etiology of liver disease, prompt diagnosis by means of laboratory tests, hepatic imaging, and often liver biopsy is required after HCT. |
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Authors:
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Josh Levitsky; Michael F Sorrell |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Current gastroenterology reports Volume: 9 ISSN: 1522-8037 ISO Abbreviation: Curr Gastroenterol Rep Publication Date: 2007 Mar |
Date Detail:
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Created Date: 2007-03-05 Completed Date: 2007-06-14 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100888896 Medline TA: Curr Gastroenterol Rep Country: United States |
Other Details:
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Languages: eng Pagination: 60-5 Citation Subset: IM |
Affiliation:
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Department of Medicine, Division of Hepatology, Northwestern University Feinberg School of Medicine, 675 N. St. Clair, 15-250, Chicago, IL 60611, USA. j-levitsky@northwestern.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Biliary Tract Diseases Drug Toxicity Graft vs Host Disease Hematopoietic Stem Cell Transplantation / adverse effects* Hepatic Veno-Occlusive Disease Hepatitis, Viral, Human Humans Iron Overload Liver Diseases / diagnosis, epidemiology, etiology* Mycoses Parenteral Nutrition, Total Risk Factors Sepsis |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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