| Hepatic clearance and retention of aluminium: studies in the isolated perfused rat liver. | |
| | |
MedLine Citation:
|
PMID: 9001595 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Aluminium (Al) exposure can result in Al accumulation in the liver and this metal can be toxic to the hepatic tissue at high concentrations. In the present study the model of the isolated perfused rat liver was used to investigate the hepatic handling of Al. Livers from male Wistar rats were perfused in a recirculating system for 240 min. The liver function remained unchanged at perfusate concentrations of Al ranging from 4.9 to 1530.0 micrograms/l. At higher Al levels of 6535.3-16694.9 micrograms/l signs of toxicity towards isolated perfused livers were observed as indicated by an increased release of the enzymes AST and ALT into the perfusate, a pronounced reduction of bile flow rate and a 50% suppression of oxygen consumption. The hepatic Al clearance was low and decreased with increasing concentrations of Al in the perfusate from 4.3 +/- 0.6 microliters/min per g liver at a nominal Al concentration of 9.1 micrograms/l in control perfusate to 0.04 +/- 0.02 microliter/min per g liver at the highest concentration group. There was almost a linear dose dependent retention of Al in the liver with 4.9-635.7 micrograms Al/l perfusate while at higher concentrations Al levels in this organ increased disproportionally. It is concluded that by using the isolated perfused rat changes of liver functions occur only at very high Al concentrations in the perfusate and that only negligible amounts of Al are eliminated by the liver. |
| | |
Authors:
|
M Wilhelm; D E Jaeger; H Schüll-Cablitz; D Hafner; H Idel |
Related Documents
:
|
1067895 - Relation of disease stage to humoral and cellular impairment of spleen reticuloendothel... 1984365 - Amino acids fail to prevent halothane depression of albumin synthesis: studies in the i... 209115 - Catabolism of the apoprotein of low density lipoproteins by the isolated perfused rat l... 15040035 - Protective effect of exogenous adenosine triphosphate on hypothermically preserved rat ... 19073285 - Serotonergic projections from the caudal raphe nuclei to the hypoglossal nucleus in mal... 6168745 - Biochemical demonstration of the myelin-associated glycoprotein in the peripheral nervo... |
Publication Detail:
|
Type: In Vitro; Journal Article |
Journal Detail:
|
Title: Toxicology letters Volume: 89 ISSN: 0378-4274 ISO Abbreviation: Toxicol. Lett. Publication Date: 1996 Dec |
Date Detail:
|
Created Date: 1997-02-12 Completed Date: 1997-02-12 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 7709027 Medline TA: Toxicol Lett Country: NETHERLANDS |
Other Details:
|
Languages: eng Pagination: 257-63 Citation Subset: IM |
Affiliation:
|
Institute of Hygiene, Heinrich-Heine-University Düsseldorf, Germany. Michael Wilhelm@uni-duesseldorf.de |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Alanine Transaminase
/
drug effects,
metabolism Aluminum / analysis, pharmacokinetics, toxicity* Animals Aspartate Aminotransferases / drug effects, metabolism Bile / drug effects, metabolism Liver / chemistry, drug effects*, pathology Male Perfusion Rats Rats, Wistar |
| Chemical | |
Reg. No./Substance:
|
7429-90-5/Aluminum; EC 2.6.1.1/Aspartate Aminotransferases; EC 2.6.1.2/Alanine Transaminase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Effect of vitamin C supplementation on hepatic cytochrome P450 mixed-function oxidase activity in st...
Next Document: A parallel broadband real-time system for electrical impedance tomography.