| Hepatic catalase and superoxide dismutases after acute ethanol administration in rats. | |
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MedLine Citation:
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PMID: 4015837 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The administration of an acute ethanol load (2.3 g/kg, IP) to rats is followed by a decrease of the hepatic activity of cytosolic catalase, a decrease which precedes a reduction in the cytosolic Cu, Zn-superoxide dismutase (SOD) activity. Desferrioxamine, an iron chelator and scavenger of superoxide radicals, administered prior to ethanol, prevents the changes in the cytosolic catalase activity, changes which are unaffected by the administration of allopurinol, an inhibitor of xanthine oxidase. These data favour the hypothesis that acute ethanol results in an overproduction of oxygen free radicals which affects primarily the cytosolic catalase activity and increases hereby susceptibility of Cu, Zn-SOD to these radicals. They suggest also that xanthine oxidase does not play a major role in oxygen radical production in the liver cytosol during acute alcohol intoxication. |
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Authors:
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C Ribiere; J Sinaceur; D Sabourault; R Nordmann |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Alcohol (Fayetteville, N.Y.) Volume: 2 ISSN: 0741-8329 ISO Abbreviation: Alcohol Publication Date: 1985 Jan-Feb |
Date Detail:
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Created Date: 1985-08-27 Completed Date: 1985-08-27 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8502311 Medline TA: Alcohol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 31-3 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Allopurinol
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pharmacology Animals Catalase / analysis* Deferoxamine / pharmacology Ethanol / administration & dosage*, pharmacology Liver / drug effects, enzymology* Male Rats Rats, Inbred Strains Superoxide Dismutase / analysis* |
| Chemical | |
Reg. No./Substance:
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315-30-0/Allopurinol; 64-17-5/Ethanol; 70-51-9/Deferoxamine; EC 1.11.1.6/Catalase; EC 1.15.1.1/Superoxide Dismutase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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