Document Detail

Hepatic artery hypertrophy and sinusoidal hypertension in advanced schistosomiasis.
MedLine Citation:
PMID:  318579     Owner:  NLM     Status:  MEDLINE    
In 5 patients with portal hypertension caused by schistosomiasis, the sinusoidal pressure (wedged hepatic pressure) varied from 20.7 to 35.4 mm Hg. While the catheter was in an occluded position within the hepatic vein and the patients were undergoing splenectomy, the main trunk of the hepatic artery was clamped. The sinusoidal pressures then fell to levels that varied from 3.7 to 7.4 mm Hg but returned to previous levels when the clamping was released. Wedged hepatic venous pressure levels, which were significantly greater than portal venous pressure values, decreased minimally after splenectomy. Portal venous pressure levels, however, fell to 63% of presplenectomy levels. In a control case with an enlarged spleen (cavernous hemangioma, but with a normal liver, the wedged hepatic pressure was 7.4 mm Hg and showed no alteration after clamping of hepatic artery. These data point out the importance of hepatic artery hypertrophy, that has already been demonstrated in other studies, in causing elevation of the wedged hepatic pressure in advanced hepatic schistosomiasis.
C A Alves; A R Alves; W N Abreu; Z A Andrade
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  Gastroenterology     Volume:  72     ISSN:  0016-5085     ISO Abbreviation:  Gastroenterology     Publication Date:  1977 Jan 
Date Detail:
Created Date:  1977-01-29     Completed Date:  1977-01-29     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0374630     Medline TA:  Gastroenterology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  126-8     Citation Subset:  AIM; IM    
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MeSH Terms
Blood Pressure
Clinical Trials as Topic
Hepatic Artery* / pathology
Hypertension, Portal / complications*,  physiopathology
Schistosomiasis / complications*,  pathology,  physiopathology
Venous Pressure

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