Document Detail


Hepatic activity in the generation of somatomedins: effects of administration of a liver extract.
MedLine Citation:
PMID:  689794     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The problem of the generation of growth factors (somatomedins) (SM) is at present a matter of investigation. The liver has been proposed as the primary site of production of SM. In order to verify this hypothesis, SM activity has been assayed in patients with impairment of liver function. The subjects have been divided into three groups according to the severity of the hepatic damage, assessed with conventional diagnostic tests. In every group, somatomedin A (ASM) has been assayed by means of a biological procedure, in basal conditions and after treatment with a liver extract. The results show that the ASM activity is reduced in proportion to the degree of hepatic damage. The administration of liver extract restores the production of the ASM in the first two groups of patients, i.e. in those with mild and moderate hepatic involvement.
Authors:
S Pallotti; D Paolucci; A Isidori
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International journal of clinical pharmacology and biopharmacy     Volume:  16     ISSN:  0340-0026     ISO Abbreviation:  Int J Clin Pharmacol Biopharm     Publication Date:  1978 Aug 
Date Detail:
Created Date:  1978-11-18     Completed Date:  1978-11-18     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7505527     Medline TA:  Int J Clin Pharmacol Biopharm     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  351-6     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Humans
Liver / metabolism*,  physiology
Liver Diseases / drug therapy,  metabolism
Liver Function Tests
Somatomedins / biosynthesis*
Tissue Extracts / pharmacology*,  therapeutic use
Chemical
Reg. No./Substance:
0/Somatomedins; 0/Tissue Extracts

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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