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Hepatic Manifestations in Juvenile Systemic Lupus Erythematosus.
MedLine Citation:
PMID:  24383439     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Juvenile systemic lupus erythematosus (JSLE) is a chronic autoimmune disease characterized by multisystem involvement and diverse clinical and serological manifestations. Clinically significant hepatic disease is generally regarded as unusual in JSLE, but many studies have showed that hepatic disease may be more common in SLE than was usually thought. Hepatic disease does not cause significant morbidity and mortality, but subclinical liver involvement is common. One of the hepatic disorders associated with JSLE is autoimmune hepatitis (AIH). The precise etiology of AIH and JSLE remains unknown, however both AIH and JSLE are associated with antinuclear antibody (ANA) and multisystem disease manifestations. A shared immunologic response and genetic predisposition were suggested. Recently, new approaches for treatment of SLE and recent patents that could develop into novel therapeutic agents in clinical management of SLE have been proposed. An array of promising new therapies are currently emerging or being developed including B-cell depletion therapies, agents targeting B-cell survival factors, blockade of T-cell co-stimulation and anti-cytokine therapies, such as monoclonal antibodies against interleukin-6 and interferon-α. In the coming review we will also report a 12-year old girl who developed JSLE four years after her preliminary diagnosis with AIH.
Authors:
Mortada H El-Shabrawi; Mona I Farrag
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-12-28
Journal Detail:
Title:  Recent patents on inflammation & allergy drug discovery     Volume:  -     ISSN:  1872-213X     ISO Abbreviation:  Recent Pat Inflamm Allergy Drug Discov     Publication Date:  2013 Dec 
Date Detail:
Created Date:  2014-1-3     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101309297     Medline TA:  Recent Pat Inflamm Allergy Drug Discov     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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