| Hepatic Lipase Gene -514C>T Variant is Associated with Exercise Training-Induced Changes in VLDL and HDL by Lipoprotein Lipase. | |
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MedLine Citation:
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PMID: 21960661 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Our objective was to test the hypothesis that a common polymorphism in the hepatic lipase (HL) gene (LIPC -514C>T, rs1800588) influences aerobic exercise training (AEX)-induced changes in TG, VLDL, and HDL through genotype-specific increases in LPL activity, and that gender may affect these responses. Seventy-six sedentary men and women aged 50-75 years at risk for CHD underwent a 24-week prospective study of the LIPC -514 genotype-specific effects of exercise training on lipoproteins measured enzymatically and by NMR, post-heparin LPL and HL activities, body composition by DXA and CT scan, and aerobic capacity. CT genotype subjects had higher baseline total cholesterol, HDL-C, HDL(2)-C, large HDL, HDL particle size, and large LDL than CC homozygotes. AEX elicited genotype-specific decreases in VLDL-TG (-22 vs. +7%; P<0.05; CC vs CT, respectively), total VLDL and medium VLDL and increases in HDL-C (+7 vs. 4%; p<0.03) and HDL(3)-C with significant genotype*gender interactions for the changes in HDL-C and HDL(3)-C (p's= 0.01-.02). There were also genotype-specific changes in LPL (+23 vs. -6%; p<0.05) and HL (+7 vs. -24%; p<0.01) activities, with LPL increasing only in CC subjects (p<0.006) and HL decreasing only in CT subjects (p<0.007). Reductions in TG, VLDL-TG, large VLDL, and medium VLDL and increases in HDL(3)-C and small HDL particles correlated significantly with changes in LPL, but not HL, activity only in CC subjects. Thus, the HL -514C>T variant significantly affects AEX-induced anti-atherogenic changes in VLDL-TG, VLDL particles and HDL by increasing LPL activity in CC subjects, which could guide therapeutic strategies to reduce CHD risk. |
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Authors:
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Tina E Brinkley; Amy Halverstadt; Dana A Phares; Robert E Ferrell; Ronald L Prigeon; James M Hagberg; Andrew P Goldberg |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-9-29 |
Journal Detail:
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Title: Journal of applied physiology (Bethesda, Md. : 1985) Volume: - ISSN: 1522-1601 ISO Abbreviation: - Publication Date: 2011 Sep |
Date Detail:
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Created Date: 2011-9-30 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8502536 Medline TA: J Appl Physiol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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1Wake Forest School of Medicine. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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