Document Detail


Hepatic hemangioendothelioma presenting as sudden unexpected death in infancy: a case report.
MedLine Citation:
PMID:  20465426     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The classification of an unexpected infant death as sudden infant death syndrome (SIDS) depends upon a complete autopsy, death scene investigation, and review of medical history to exclude known causes of death. Death from occult neoplastic disease in infancy is extremely rare but is within the broad differential diagnosis of SIDS. We report the sudden and unexpected death of a 1-month-old infant from a hepatic (infantile) hemangioendothelioma. The physiologic mechanism of death was likely cardiac failure induced by the circulatory demands of this large vascular tumor and respiratory compromise from diaphragmatic thoracic incursion. The clinical progression and pathology of these relatively common tumors of infant livers are extremely variable. This case dramatically illustrates the potential for fatal outcome of this tumor, as well as the need for autopsy to determine the cause of sudden and unexpected death in an infant.
Authors:
Johan Dempers; Shabbir Ahmed Wadee; Theonia Boyd; Colleen Wright; Hein J Odendaal; Mary Ann Sens;
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, N.I.H., Extramural     Date:  2010-05-13
Journal Detail:
Title:  Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society     Volume:  14     ISSN:  1093-5266     ISO Abbreviation:  Pediatr. Dev. Pathol.     Publication Date:    2011 Jan-Feb
Date Detail:
Created Date:  2011-04-19     Completed Date:  2011-06-02     Revised Date:  2014-08-27    
Medline Journal Info:
Nlm Unique ID:  9809673     Medline TA:  Pediatr Dev Pathol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  71-4     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Diagnosis, Differential
Hemangioendothelioma / complications,  pathology*
Humans
Infant
Liver Neoplasms / complications,  pathology*
Male
Sudden Infant Death / etiology*
Grant Support
ID/Acronym/Agency:
U01 AA016501/AA/NIAAA NIH HHS; U01 AA016501/AA/NIAAA NIH HHS; U01 HD045935/HD/NICHD NIH HHS; U01 HD045935/HD/NICHD NIH HHS; U01 HD045991/HD/NICHD NIH HHS; U01 HD045991/HD/NICHD NIH HHS; U01 HD055154/HD/NICHD NIH HHS; U01 HD055154/HD/NICHD NIH HHS; U01 HD055155/HD/NICHD NIH HHS; U01 HD055155/HD/NICHD NIH HHS
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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