| Hepatic gene expression related to lower plasma cholesterol in hamsters fed high-fat diets supplemented with blueberry peels and peel extract. | |
| | |
MedLine Citation:
|
PMID: 20143813 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
This study analyzed plasma lipid profiles, genes related to cholesterol and bile acid metabolism, and inflammation in liver as well as adipose tissue from Syrian Golden hamsters fed high-fat diets supplemented with blueberry (BB) pomace byproducts including 8% dried whole blueberry peels (BBPWHL), 2% dried extract of peels (BBPX; 95% ethanol extract), and 6% residue from extracted peel (BBPEXT) compared to a diet containing 5% (w/w) microcrystalline cellulose (control). All BB diets significantly lowered plasma very low density lipoprotein cholesterol and total cholesterol concentrations. Interestingly, BB diets increased fecal lipid excretion. Hepatic CYP7A1 expression was up-regulated by all BB diets, and the expression of CYP51 was up-regulated by BBPX and BBPEXT diets, suggesting that both bile acid and cholesterol synthesis were increased. No significant changes in adipocyte gene expression related to inflammatory markers were observed with any BB diet. These data suggest that hepatic modulation of bile acid and cholesterol synthesis primarily contributes to the cholesterol-lowering effect of BB pomace byproducts. |
| | |
Authors:
|
Hyunsook Kim; Glenn E Bartley; Agnes M Rimando; Wallace Yokoyama |
Related Documents
:
|
7055593 - Biosynthesis of dolichol and cholesterol during embryonic development of the chicken. 845503 - Sterol metabolism studies in the rat. effects of primary bile acids (sodium taurochenod... 21523363 - Lipid profile in tunisian patients with rheumatoid arthritis. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Journal of agricultural and food chemistry Volume: 58 ISSN: 1520-5118 ISO Abbreviation: J. Agric. Food Chem. Publication Date: 2010 Apr |
Date Detail:
|
Created Date: 2010-04-07 Completed Date: 2010-08-31 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0374755 Medline TA: J Agric Food Chem Country: United States |
Other Details:
|
Languages: eng Pagination: 3984-91 Citation Subset: IM |
Affiliation:
|
Processed Foods Research, Western Regional Research Center, Agricultural Research Service, U.S. Department of Agriculture, Albany, Calfifornia 94710, USA. Hyunsook.Kim@ars.usda.gov |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Anticholesteremic Agents / administration & dosage* Blueberry Plant / chemistry* Cholesterol / blood* Cholesterol 7-alpha-Hydroxylase / genetics, metabolism Cricetinae Dietary Fats / administration & dosage, adverse effects Gene Expression / drug effects* Liver / drug effects, metabolism* Male Mesocricetus Plant Extracts / administration & dosage* Random Allocation |
| Chemical | |
Reg. No./Substance:
|
0/Anticholesteremic Agents; 0/Dietary Fats; 0/Plant Extracts; 57-88-5/Cholesterol; EC 1.14.13.17/Cholesterol 7-alpha-Hydroxylase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Mechanistic insights on riboflavin synthase inspired by selective binding of the 6,7-dimethyl-8-ribi...
Next Document: Polcalcin divalent ion-binding behavior and thermal stability: comparison of Bet v 4, Bra n 1, and B...