| Hepatic effects of rosiglitazone in rats with the metabolic syndrome. | |
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MedLine Citation:
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PMID: 20210788 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Rats given fructose-enriched diet develop many characteristics of the human metabolic syndrome and non-alcoholic fatty liver disease. In this study, we characterized the hepatic effects of rosiglitazone in fructose-enriched diet rats. Rats were randomly divided into three groups. One group was maintained on standard rat chow diet for 6 weeks, whereas the other two groups were given fructose-enriched diet for 6 weeks. Four weeks after the initiation of fructose-enriched diet, one of the fructose-enriched diet groups was also given rosiglitazone (10 mg/kg/day) for an additional 2 weeks. Rosiglitazone administration to the fructose-enriched diet rats was associated with decreases in the following parameters: blood pressure (-17%), plasma triglycerides (-62%), hepatic total lipids (-19%), hepatic triglycerides (-61%), hepatic malondialdehyde (-88%), glutathione reductase activity (-84%). An increase in adiponectin plasma levels (+329%), hepatic phospholipids (+46%), hepatic alpha-tocopherol concentrations (+24%) and hepatic paraoxonase activity (+68%) was observed. Rosiglitazone caused a decrease in hepatic macrovesicular steatosis score but no change in hepatic fibrosis. Administration of rosiglitazone, to rats with the metabolic syndrome has limited hepatic favourable effects: it improves hepatic lipid metabolism, decreases macrovesicular steatosis and improves some of the hepatic oxidative-anti-oxidative milieu but has no effect on hepatic fibrosis. |
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Authors:
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Zvi Ackerman; Mor Oron-Herman; Orit Pappo; Edna Peleg; Rifaat Safadi; Hemda Schmilovitz-Weiss; Maria Grozovski |
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Publication Detail:
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Type: Journal Article Date: 2010-03-04 |
Journal Detail:
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Title: Basic & clinical pharmacology & toxicology Volume: 107 ISSN: 1742-7843 ISO Abbreviation: Basic Clin. Pharmacol. Toxicol. Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-07-28 Completed Date: 2010-11-05 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101208422 Medline TA: Basic Clin Pharmacol Toxicol Country: Denmark |
Other Details:
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Languages: eng Pagination: 663-8 Citation Subset: IM |
Affiliation:
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Department of Medicine, Mount Scopus Campus, Hadassah-Hebrew University Medical Center, Jerusalem, Israel. zackerman@hadassah.org.il |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adiponectin
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metabolism Animal Feed Animals Aryldialkylphosphatase / metabolism Blood Pressure / drug effects Fatty Liver / chemically induced, drug therapy, metabolism Fructose / administration & dosage Glutathione Reductase / metabolism Hypoglycemic Agents / pharmacology* Lipid Metabolism / drug effects Lipids / analysis Liver / drug effects*, metabolism Liver Cirrhosis / chemically induced, drug therapy, metabolism Male Malondialdehyde / metabolism Metabolic Syndrome X / chemically induced, drug therapy* Phospholipids / metabolism Rats Rats, Sprague-Dawley Thiazolidinediones / pharmacology* alpha-Tocopherol / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Adiponectin; 0/Hypoglycemic Agents; 0/Lipids; 0/Phospholipids; 0/Thiazolidinediones; 122320-73-4/rosiglitazone; 30237-26-4/Fructose; 542-78-9/Malondialdehyde; 59-02-9/alpha-Tocopherol; EC 1.8.1.7/Glutathione Reductase; EC 3.1.8.1/Aryldialkylphosphatase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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