| Hepatic Arterial Infusion Chemotherapy for Advanced Hepatocellular Carcinoma according to Child Pugh Classification. | |
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MedLine Citation:
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PMID: 23020312 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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OBJECTIVE.: We compared the treatment response, survival and safety to hepatic arterial infusion chemotherapy (HAIC) in patients with advanced hepatocellular carcinoma (HCC) according to Child-Pugh (CP) score. METHODS.: The study subjects were 249 patients with advanced HCC and CP class A and B who had been treated with HAIC. Patients were grouped according to CP score (5/6, 7 and 8/9) and their tumor response, tolerance, and survival were assessed. RESULTS.: The median survival time (MST) was 8.2, 9.7, 6.3 and 3.9 months for the whole group, patients with CP 5/6, 7 and 8/9, respectively (P<0.0001). Complete response (CR) and partial response (PR) were seen in 11 and 57 patients, respectively, with an overall response rate of 27.3%. The response rate was higher in patients with CP score 5/6 and 7, than CP 8/9 (30.5%, 28.2%, 13.8%). The dropout rate was significantly higher in patients with CP score 8/9 than the other two (8.0%, 12.8%, 33.3%, respectively). The survival rate was significantly better in patients who achieved CR/PR than the others with CP score 5/6, 7. CP score 8/9 was an independent negative factor for response and survival. CONCLUSION.: Advanced HCC patients with CP score of 5/6 and 7 showed a better response to HAIC and better prognosis than those with CP score 8/9. |
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Authors:
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Daisuke Miyaki; Hiroshi Aikata; Yohji Honda; Noriaki Naeshiro; Takashi Nakahara; Mio Tanaka; Yuko Nagaoki; Tomokazu Kawaoka; Shintaro Takaki; Koji Waki; Akira Hiramatsu; Shoichi Takahashi; Masaki Ishikawa; Hideaki Kakizawa; Kazuo Awai; Kazuaki Chayama |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-9-28 |
Journal Detail:
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Title: Journal of gastroenterology and hepatology Volume: - ISSN: 1440-1746 ISO Abbreviation: J. Gastroenterol. Hepatol. Publication Date: 2012 Sep |
Date Detail:
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Created Date: 2012-10-1 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8607909 Medline TA: J Gastroenterol Hepatol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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© 2012 Journal of Gastroenterology and Hepatology Foundation and Wiley Publishing Asia Pty Ltd. |
Affiliation:
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Department of Medicine and Molecular Science, Division of Frontier Medical Science, Programs for Biomedical Research, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, 734-8551, Japan. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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