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Hepatic Arterial Infusion Chemotherapy for Advanced Hepatocellular Carcinoma according to Child Pugh Classification.
MedLine Citation:
PMID:  23020312     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
OBJECTIVE.: We compared the treatment response, survival and safety to hepatic arterial infusion chemotherapy (HAIC) in patients with advanced hepatocellular carcinoma (HCC) according to Child-Pugh (CP) score. METHODS.: The study subjects were 249 patients with advanced HCC and CP class A and B who had been treated with HAIC. Patients were grouped according to CP score (5/6, 7 and 8/9) and their tumor response, tolerance, and survival were assessed. RESULTS.: The median survival time (MST) was 8.2, 9.7, 6.3 and 3.9 months for the whole group, patients with CP 5/6, 7 and 8/9, respectively (P<0.0001). Complete response (CR) and partial response (PR) were seen in 11 and 57 patients, respectively, with an overall response rate of 27.3%. The response rate was higher in patients with CP score 5/6 and 7, than CP 8/9 (30.5%, 28.2%, 13.8%). The dropout rate was significantly higher in patients with CP score 8/9 than the other two (8.0%, 12.8%, 33.3%, respectively). The survival rate was significantly better in patients who achieved CR/PR than the others with CP score 5/6, 7. CP score 8/9 was an independent negative factor for response and survival. CONCLUSION.: Advanced HCC patients with CP score of 5/6 and 7 showed a better response to HAIC and better prognosis than those with CP score 8/9.
Authors:
Daisuke Miyaki; Hiroshi Aikata; Yohji Honda; Noriaki Naeshiro; Takashi Nakahara; Mio Tanaka; Yuko Nagaoki; Tomokazu Kawaoka; Shintaro Takaki; Koji Waki; Akira Hiramatsu; Shoichi Takahashi; Masaki Ishikawa; Hideaki Kakizawa; Kazuo Awai; Kazuaki Chayama
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-9-28
Journal Detail:
Title:  Journal of gastroenterology and hepatology     Volume:  -     ISSN:  1440-1746     ISO Abbreviation:  J. Gastroenterol. Hepatol.     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-10-1     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8607909     Medline TA:  J Gastroenterol Hepatol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2012 Journal of Gastroenterology and Hepatology Foundation and Wiley Publishing Asia Pty Ltd.
Affiliation:
Department of Medicine and Molecular Science, Division of Frontier Medical Science, Programs for Biomedical Research, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, 734-8551, Japan.
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