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Hepatic Arterial Infusion Chemotherapy for Advanced Hepatocellular Carcinoma according to Child Pugh Classification.
MedLine Citation:
PMID:  23020312     Owner:  NLM     Status:  Publisher    
OBJECTIVE.: We compared the treatment response, survival and safety to hepatic arterial infusion chemotherapy (HAIC) in patients with advanced hepatocellular carcinoma (HCC) according to Child-Pugh (CP) score. METHODS.: The study subjects were 249 patients with advanced HCC and CP class A and B who had been treated with HAIC. Patients were grouped according to CP score (5/6, 7 and 8/9) and their tumor response, tolerance, and survival were assessed. RESULTS.: The median survival time (MST) was 8.2, 9.7, 6.3 and 3.9 months for the whole group, patients with CP 5/6, 7 and 8/9, respectively (P<0.0001). Complete response (CR) and partial response (PR) were seen in 11 and 57 patients, respectively, with an overall response rate of 27.3%. The response rate was higher in patients with CP score 5/6 and 7, than CP 8/9 (30.5%, 28.2%, 13.8%). The dropout rate was significantly higher in patients with CP score 8/9 than the other two (8.0%, 12.8%, 33.3%, respectively). The survival rate was significantly better in patients who achieved CR/PR than the others with CP score 5/6, 7. CP score 8/9 was an independent negative factor for response and survival. CONCLUSION.: Advanced HCC patients with CP score of 5/6 and 7 showed a better response to HAIC and better prognosis than those with CP score 8/9.
Daisuke Miyaki; Hiroshi Aikata; Yohji Honda; Noriaki Naeshiro; Takashi Nakahara; Mio Tanaka; Yuko Nagaoki; Tomokazu Kawaoka; Shintaro Takaki; Koji Waki; Akira Hiramatsu; Shoichi Takahashi; Masaki Ishikawa; Hideaki Kakizawa; Kazuo Awai; Kazuaki Chayama
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-9-28
Journal Detail:
Title:  Journal of gastroenterology and hepatology     Volume:  -     ISSN:  1440-1746     ISO Abbreviation:  J. Gastroenterol. Hepatol.     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-10-1     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8607909     Medline TA:  J Gastroenterol Hepatol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2012 Journal of Gastroenterology and Hepatology Foundation and Wiley Publishing Asia Pty Ltd.
Department of Medicine and Molecular Science, Division of Frontier Medical Science, Programs for Biomedical Research, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, 734-8551, Japan.
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