Document Detail


Hepatic 3 alpha-dehydrogenation and 7 alpha-hydroxylation of deoxycholic acid in the guinea-pig.
MedLine Citation:
PMID:  3816155     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The metabolic fate of exogenous deoxycholate administered either intraperitoneally or intragastrically to male Hartley guinea-pigs was investigated. Two animals received a constant infusion of [24-14C]deoxycholate through an intraperitoneal catheter for 2 hr. Bile was quantitatively collected in 30 min samples during infusion and for 2 additional hours. Each bile sample was analyzed for composition and radioactivity. Five animals received for 15 days, through an intragastric catheter, 35 mg/kg/day of deoxycholate. The biliary bile acid composition was compared with that of a sham-operated control group. The studies with both animal models indicated that guinea-pigs, as the only species so far known, extensively oxidize deoxycholate to form 3-oxo,12 alpha-hydroxy-cholanic acid, which is secreted in bile mostly conjugated with glycine. In addition a small fraction (approx. 7%) of the administered deoxycholate is 7 alpha hydroxylated to form cholic acid. The metabolites being more hydrophilic than administered deoxycholate, it is suggested that guinea-pig liver counteracts the adverse increase in bile acids detergency, which follows deoxycholate administration, by converting most of the latter into less detergent compounds.
Authors:
A Cantafora; D Alvaro; A F Attili; A Di Biase; M Anza; A Mantovani; M Angelico
Related Documents :
921765 - Effect of lipophilic character on the biological activity of synthetic angiotensin pept...
6259025 - Morphochemical investigations of the liver and biochemical studies of the blood of guin...
2505505 - N-butyl 2-cyanoacrylate--substitute for ibca in interventional neuroradiology: histopat...
8954905 - Peptidyl conjugates of adenosine 5'-carboxylic acid synthesized and evaluated as ligand...
18964365 - Potentiometric titration of fulvic acids from lignite, in dimethylformamide and dimethy...
2296035 - 5-[(aminoalkyl)amino]imidazo[4,5,1-de]acridin-6-ones as a novel class of antineoplastic...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Comparative biochemistry and physiology. B, Comparative biochemistry     Volume:  85     ISSN:  0305-0491     ISO Abbreviation:  Comp. Biochem. Physiol., B     Publication Date:  1986  
Date Detail:
Created Date:  1987-03-30     Completed Date:  1987-03-30     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  2984730R     Medline TA:  Comp Biochem Physiol B     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  805-10     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Administration, Oral
Animals
Bile Acids and Salts / metabolism
Carbon Radioisotopes
Chromatography, High Pressure Liquid
Deoxycholic Acid / administration & dosage,  metabolism*
Guinea Pigs
Hydroxylation
Injections, Intraperitoneal
Kinetics
Liver / metabolism*
Male
Oxidation-Reduction
Chemical
Reg. No./Substance:
0/Bile Acids and Salts; 0/Carbon Radioisotopes; 83-44-3/Deoxycholic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Phosphatidylethanolamine methyltransferase activity in chick liver microsomes.
Next Document:  Comparative study of the structure of glyceraldehyde-3-phosphate dehydrogenase from bovine heart mus...