| Heparinization of biological vascular graft reduces fibrin deposition. | |
| | |
MedLine Citation:
|
PMID: 8354585 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
An alternative graft is needed for coronary bypass operations in patients lacking suitable autologous vessels. We therefore studied Denaflex, a biologic graft, in a dog ex-vivo shunt model to determine whether heparin treatment makes this graft less thrombogenic. Comparison was also made to Bioflow, a nonheparinized biologic graft. Fibrinogen deposition during high flow (593 +/- 202 ml/min) decreased from 672 +/- 467 ng/mm2 in nonheparinized Denaflex grafts to 448 +/- 298 ng/mm2 (p < 0.05) in heparinized Denaflex grafts. At low flow (117 +/- 13 ml/min), heparinization of Denaflex grafts similarly decreased fibrinogen deposition from 1102 +/- 601 ng/mm2 to 703 +/- 405 ng/mm2 (p < 0.05). At both flow rates fibrinogen deposition in Bioflow grafts was less than in nonheparinized Denaflex, but was similar to heparinized Denaflex grafts. Platelet deposition was not influenced by heparinization of Denaflex grafts and was similar among Denaflex and Bioflow preparations. Whether Denaflex performs acceptably in vivo as a xenograft requires extensive study. |
| | |
Authors:
|
L E Boerboom; G N Olinger; B J Karas; J N Lindon; L Z Rosen; K Thyagarajan; R Tu |
Related Documents
:
|
2406975 - Postoperative surveillance of infrainguinal bypass. 17680515 - Single versus sequential saphenous vein grafting of the circumflex system: a flowmetric... 10855555 - Comparison of anastomotic microcirculation in coloanal j-pouches versus straight and si... 7614315 - Vascular access and nephrology nursing practice: existing views and rationales for change. 7123135 - The development of the hypothalamo-hypophysial portal system in human fetus. 2446985 - Oxygen transport to tissue modified by entrapment of an allosteric effector of haemoglo... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: The International journal of artificial organs Volume: 16 ISSN: 0391-3988 ISO Abbreviation: Int J Artif Organs Publication Date: 1993 May |
Date Detail:
|
Created Date: 1993-09-23 Completed Date: 1993-09-23 Revised Date: 2003-11-14 |
Medline Journal Info:
|
Nlm Unique ID: 7802649 Medline TA: Int J Artif Organs Country: ITALY |
Other Details:
|
Languages: eng Pagination: 263-7 Citation Subset: IM |
Affiliation:
|
Department of Cardiothoracic Surgery, Medical College of Wisconsin, Milwaukee. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Bioprosthesis* Blood Coagulation / drug effects Blood Flow Velocity Blood Platelets / physiology Blood Vessel Prosthesis* Coronary Artery Bypass Dogs Fibrin / metabolism Heparin* Thrombosis / etiology, physiopathology |
| Chemical | |
Reg. No./Substance:
|
9001-31-4/Fibrin; 9005-49-6/Heparin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Catheter-implanted prosthetic heart valves. Transluminal catheter implantation of a new expandable a...
Next Document: Use of the microdialysis technique in the monitoring of subcutaneous tissue glucose concentration.