Document Detail


Heparin treatment in pregnancy loss: Potential therapeutic benefits beyond anticoagulation.
MedLine Citation:
PMID:  15949561     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Interventions with heparin therapies have increased fetal survival in patients with antiphospholipid syndrome (APS). In this review, several physiological and pharmacological effects of heparin are described. These different mechanisms of action could explain the beneficial effects of heparin in the treatment of recurrent pregnancy loss in patients with APS. In addition to direct effects of heparin on the coagulation cascade, heparin might protect pregnancies by reducing the binding of antiphospholipid antibodies, reducing inflammation, facilitating implantation and or inhibiting complement activation.
Authors:
Guillermina Girardi
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Journal of reproductive immunology     Volume:  66     ISSN:  0165-0378     ISO Abbreviation:  J. Reprod. Immunol.     Publication Date:  2005 Jun 
Date Detail:
Created Date:  2005-06-13     Completed Date:  2005-10-18     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  8001906     Medline TA:  J Reprod Immunol     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  45-51     Citation Subset:  IM    
Affiliation:
Department of Medicine, Hospital for Special Surgery-Weill Medical College of Cornell University, New York, NY 10021, USA. girardig@hss.edu
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MeSH Terms
Descriptor/Qualifier:
Abortion, Habitual / drug therapy*,  etiology
Antibodies, Antiphospholipid / immunology
Anticoagulants / pharmacology,  therapeutic use*
Antigen-Antibody Reactions / drug effects
Antiphospholipid Syndrome / complications*
Complement Inactivator Proteins / pharmacology,  physiology,  therapeutic use*
Complement System Proteins / drug effects
Embryo Implantation / drug effects
Female
Heparin / pharmacology,  physiology,  therapeutic use*
Humans
Pregnancy
Chemical
Reg. No./Substance:
0/Antibodies, Antiphospholipid; 0/Anticoagulants; 0/Complement Inactivator Proteins; 9005-49-6/Heparin; 9007-36-7/Complement System Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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