Document Detail

Heparin therapy for recent transient focal cerebral ischemia.
MedLine Citation:
PMID:  3682955     Owner:  NLM     Status:  MEDLINE    
The Mayo Clinic medical records and records linkage system were used to identify stroke-free residents of Rochester, Minnesota, who were examined within 30 days after the first transient cerebral ischemic attack (TIA) during the period 1955 through 1979. The patients were divided into two groups: those given heparin within 30 days after the first attack and those not given heparin. Death, stroke, and either stroke or TIA were separate endpoints in Kaplan-Meier analyses of data from the day of initial examination through the 30th day thereafter. The probabilities of survival, survival free from stroke, and survival free from TIA for the heparin-treated group were not significantly different from those probabilities for the comparison group. The rate of hemorrhagic complications was 3.2 per 100 person-days of heparin therapy. Retroperitoneal hemorrhage, the most serious complication, was the cause of one death and one case of femoral neuropathy.
D S Keith; S J Phillips; J P Whisnant; K Nishimaru; W M O'Fallon
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Mayo Clinic proceedings     Volume:  62     ISSN:  0025-6196     ISO Abbreviation:  Mayo Clin. Proc.     Publication Date:  1987 Dec 
Date Detail:
Created Date:  1988-01-20     Completed Date:  1988-01-20     Revised Date:  2013-12-13    
Medline Journal Info:
Nlm Unique ID:  0405543     Medline TA:  Mayo Clin Proc     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1101-6     Citation Subset:  AIM; IM    
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MeSH Terms
Cause of Death
Heparin / adverse effects,  therapeutic use*
Ischemic Attack, Transient / drug therapy*,  mortality,  pathology
Grant Support
Reg. No./Substance:
Erratum In:
Mayo Clin Proc 1988 Jan;63(1):92

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