Document Detail


Heparin therapy during pregnancy. Risks to the fetus and mother.
MedLine Citation:
PMID:  2802889     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The true maternal and fetal risks of heparin therapy during pregnancy are unknown, because most published studies are small and do not report consecutively treated patients. In order to address these issues, we performed a retrospective cohort study of 100 pregnancies in 77 women treated with heparin during pregnancy. In 98 pregnancies heparin therapy was given for the prevention or treatment of venous thromboembolism; in the remaining 2, because of prosthetic heart valves. The rates of prematurity, abortions, stillbirths, neonatal deaths, and congenital abnormalities were similar to those in the normal population. There were two bleeding episodes and no symptomatic thrombotic episodes associated with heparin therapy. We conclude that maternal heparin therapy is safe for the fetus and is associated with an acceptable bleeding rate and a low rate of thrombotic recurrence in the mother.
Authors:
J S Ginsberg; G Kowalchuk; J Hirsh; P Brill-Edwards; R Burrows
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Archives of internal medicine     Volume:  149     ISSN:  0003-9926     ISO Abbreviation:  Arch. Intern. Med.     Publication Date:  1989 Oct 
Date Detail:
Created Date:  1989-11-09     Completed Date:  1989-11-09     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372440     Medline TA:  Arch Intern Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  2233-6     Citation Subset:  AIM; IM    
Affiliation:
Department of Medicine, McMaster University, Hamilton, Canada.
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MeSH Terms
Descriptor/Qualifier:
Abnormalities, Drug-Induced
Adult
Cohort Studies
Female
Heart Valve Prosthesis
Heparin / adverse effects,  therapeutic use*
Humans
Obstetric Labor, Premature / chemically induced
Ontario
Pregnancy
Pregnancy Complications, Cardiovascular / drug therapy*
Pregnancy Outcome
Retrospective Studies
Thromboembolism / drug therapy
Uterine Hemorrhage / chemically induced
Chemical
Reg. No./Substance:
9005-49-6/Heparin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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