| Heparin: a review of its pharmacology and therapeutic use in horses. | |
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MedLine Citation:
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PMID: 8176660 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Heparin is used clinically in horses to treat hemostatic abnormalities associated with severe gastrointestinal disease, septicemia, and endotoxemia. The primary anticoagulant effect of heparin is through the suppression of thrombin-dependent amplification of the coagulation cascade, and inhibition of thrombin-mediated conversion of fibrinogen to fibrin. Heparin may be of benefit in preventing the complications associated with hypercoagulable states such as jugular vein thrombosis, laminitis, and organ failure. Heparin may also be beneficial in the prevention of intraabdominal adhesions after gastrointestinal surgery, and in amelioration of hemodynamic abnormalities associated with endotoxic shock. Because a sequential rise in serum heparin concentration occurs during a uniform dosage regimen, a decreasing dosage regimen is recommended. The initial dose recommended is 150 U heparin/kg body weight subcutaneously, followed by 125 U heparin/kg body weight subcutaneously, every 12 hours for six doses. The dose should be decreased to 100 U heparin/kg body weight subcutaneously, every 12 hours, after the seventh dose. Anemia, hemorrhage, thrombocytopenia, and painful swelling at injection sites are complications of heparin administration in horses. |
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Authors:
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B R Moore; K W Hinchcliff |
Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Journal of veterinary internal medicine / American College of Veterinary Internal Medicine Volume: 8 ISSN: 0891-6640 ISO Abbreviation: J. Vet. Intern. Med. Publication Date: 1994 Jan-Feb |
Date Detail:
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Created Date: 1994-06-06 Completed Date: 1994-06-06 Revised Date: 2005-11-16 |
Medline Journal Info:
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Nlm Unique ID: 8708660 Medline TA: J Vet Intern Med Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 26-35 Citation Subset: IM |
Affiliation:
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Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Ohio State University, Columbus. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Disseminated Intravascular Coagulation / drug therapy, veterinary Heparin / adverse effects, pharmacokinetics*, therapeutic use* Horse Diseases / drug therapy* Horses Postoperative Complications / prevention & control, veterinary |
| Chemical | |
Reg. No./Substance:
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9005-49-6/Heparin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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