Document Detail


Heparin: a review of its pharmacology and therapeutic use in horses.
MedLine Citation:
PMID:  8176660     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Heparin is used clinically in horses to treat hemostatic abnormalities associated with severe gastrointestinal disease, septicemia, and endotoxemia. The primary anticoagulant effect of heparin is through the suppression of thrombin-dependent amplification of the coagulation cascade, and inhibition of thrombin-mediated conversion of fibrinogen to fibrin. Heparin may be of benefit in preventing the complications associated with hypercoagulable states such as jugular vein thrombosis, laminitis, and organ failure. Heparin may also be beneficial in the prevention of intraabdominal adhesions after gastrointestinal surgery, and in amelioration of hemodynamic abnormalities associated with endotoxic shock. Because a sequential rise in serum heparin concentration occurs during a uniform dosage regimen, a decreasing dosage regimen is recommended. The initial dose recommended is 150 U heparin/kg body weight subcutaneously, followed by 125 U heparin/kg body weight subcutaneously, every 12 hours for six doses. The dose should be decreased to 100 U heparin/kg body weight subcutaneously, every 12 hours, after the seventh dose. Anemia, hemorrhage, thrombocytopenia, and painful swelling at injection sites are complications of heparin administration in horses.
Authors:
B R Moore; K W Hinchcliff
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Journal of veterinary internal medicine / American College of Veterinary Internal Medicine     Volume:  8     ISSN:  0891-6640     ISO Abbreviation:  J. Vet. Intern. Med.     Publication Date:    1994 Jan-Feb
Date Detail:
Created Date:  1994-06-06     Completed Date:  1994-06-06     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  8708660     Medline TA:  J Vet Intern Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  26-35     Citation Subset:  IM    
Affiliation:
Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Ohio State University, Columbus.
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MeSH Terms
Descriptor/Qualifier:
Animals
Disseminated Intravascular Coagulation / drug therapy,  veterinary
Heparin / adverse effects,  pharmacokinetics*,  therapeutic use*
Horse Diseases / drug therapy*
Horses
Postoperative Complications / prevention & control,  veterinary
Chemical
Reg. No./Substance:
9005-49-6/Heparin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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