Document Detail

Heparin resistance after intraoperative platelet-rich plasma harvesting.
MedLine Citation:
PMID:  1597982     Owner:  NLM     Status:  MEDLINE    
Records of anticoagulation for cardiopulmonary bypass from 58 patients who underwent elective coronary artery revascularization were analyzed to determine whether the harvesting of autologous platelet-rich plasma produces heparin resistance. The effect of preoperative heparin therapy on anticoagulation for cardiopulmonary bypass after harvesting of platelet-rich plasma was also evaluated. Patients were grouped by presence of preoperative heparin therapy and type of blood component harvested before cardiopulmonary bypass, including platelet-rich plasma, autologous whole blood, both, or neither. The dose of heparin required to initiate and to maintain anticoagulation for cardiopulmonary bypass was determined for each patient, and the groups were compared by two-way analysis of variance. Significantly more heparin was required to maintain anticoagulation for cardiopulmonary bypass in the platelet-rich plasma group than in the groups receiving autologous whole blood or no blood products. More heparin was also required to initiate and to maintain anticoagulation for cardiopulmonary bypass after preoperative heparin therapy. These results reinforce the concept that anticoagulation during cardiopulmonary bypass must be carefully monitored, and increased vigilance may be warranted in patients after harvesting of platelet-rich plasma.
G S Wickey; J C Keifer; D R Larach; M R Diaz; D R Williams
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of thoracic and cardiovascular surgery     Volume:  103     ISSN:  0022-5223     ISO Abbreviation:  J. Thorac. Cardiovasc. Surg.     Publication Date:  1992 Jun 
Date Detail:
Created Date:  1992-07-06     Completed Date:  1992-07-06     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0376343     Medline TA:  J Thorac Cardiovasc Surg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1172-6     Citation Subset:  AIM; IM    
Department of Anesthesia, University Hospital, Pennsylvania State University College of Medicine, Hershey.
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MeSH Terms
Analysis of Variance
Blood Coagulation / drug effects
Blood Transfusion, Autologous / statistics & numerical data
Cardiopulmonary Bypass / statistics & numerical data
Dose-Response Relationship, Drug
Drug Resistance
Extracorporeal Circulation
Heparin / administration & dosage,  pharmacology*
Intraoperative Care*
Plasmapheresis* / statistics & numerical data
Platelet Transfusion*
Preoperative Care
Reg. No./Substance:

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