| Heparin reduces the intimal hyperplasia seen in microvascular vein grafts. | |
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MedLine Citation:
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PMID: 1755775 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The influence of heparin on microvascular vein graft intimal hyperplasia was studied in a rat model. The iliolumbar vein was grafted into the iliac artery in 80 rats. Heparin was delivered via a subcutaneous miniosmotic pump, starting either 2 days before grafting (early heparin group, n = 20) or immediately after grafting (heparin group, n = 30). Saline-containing pumps were placed in the control group (n = 30). Heparin activity was measured at 24 h, and again 3 weeks later when the animals were sacrificed. The grafts were harvested and prepared for histological examination. The intimal thickness was measured at the anastomoses and in the mid-graft region using an eye-piece graticule set at right angles to the graft internal elastic lamina. Heparin significantly reduced the intimal thickness at the anastomoses, from a median of 38 microns (range: 10-100 microns) in the control group to a median of 20 microns (range: 10-150 microns) in the heparin group. A similar reduction was seen in the mid-graft region. Although intimal thickening was reduced in the early heparin group, this reduction failed to reach statistical significance. The possible clinical application is discussed. |
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Authors:
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P E Norman; A K House |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The Australian and New Zealand journal of surgery Volume: 61 ISSN: 0004-8682 ISO Abbreviation: Aust N Z J Surg Publication Date: 1991 Dec |
Date Detail:
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Created Date: 1992-01-28 Completed Date: 1992-01-28 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0373115 Medline TA: Aust N Z J Surg Country: AUSTRALIA |
Other Details:
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Languages: eng Pagination: 942-8 Citation Subset: IM |
Affiliation:
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University Department of Surgery, Queen Elizabeth II Medical Centre, Nedlands, Western Australia. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anastomosis, Surgical Animals Blood Vessel Prosthesis Endothelium, Vascular / drug effects Graft Occlusion, Vascular / prevention & control* Heparin / administration & dosage, pharmacology, therapeutic use* Hyperplasia / prevention & control Iliac Artery / surgery Leg / blood supply* Microcirculation / surgery Muscle, Smooth, Vascular / drug effects* Rats Rats, Inbred WF Veins / pathology, transplantation |
| Chemical | |
Reg. No./Substance:
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9005-49-6/Heparin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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