| Heparin plus aspirin as a "single" therapy for recurrent spontaneous abortion associated with both allo- and autoimmunity. | |
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MedLine Citation:
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PMID: 10374704 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PROBLEM: The aim of this study was to contribute to the study of the pathogenesis and the treatment of recurrent spontaneous abortion (RSA) associated with immune alterations. METHOD OF STUDY: This is a prospective clinical trial with 11 patients with RSA associated with allo- and autoimmunity not receiving lymphocyte immunizations but only heparin and aspirin preconceptionally and through pregnancy. A concurrent group of 8 patients receiving a complete therapy (lymphocyte immunizations, heparin, and aspirin) but not receiving heparin and aspirin preconceptionally is also included in this report. RESULTS: The rate of pregnancy success in these patients was 90.9% (10/11), and the rate of success of the concurrent group was 75.0% (6/8). CONCLUSIONS: The results are in agreement with the working hypothesis regarding the possible final common mechanism in the pathogenesis of abortion associated with allo- and autoimmunity. The "single" therapy with heparin and aspirin was effective, less costly, and logistically simpler to provide than a complete therapy including lymphocyte immunizations. |
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Authors:
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A Cadavid; B Peña; G García; J Botero; F Sánchez; J Ossa; A Beer |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: American journal of reproductive immunology (New York, N.Y. : 1989) Volume: 41 ISSN: 1046-7408 ISO Abbreviation: Am. J. Reprod. Immunol. Publication Date: 1999 Apr |
Date Detail:
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Created Date: 1999-08-12 Completed Date: 1999-08-12 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8912860 Medline TA: Am J Reprod Immunol Country: DENMARK |
Other Details:
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Languages: eng Pagination: 271-8 Citation Subset: IM |
Affiliation:
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Reproduction Program, School of Medicine, University of Antioquia, Medellin, Colombia. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Abortion, Habitual
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immunology,
prevention & control* Adult Anticoagulants / therapeutic use* Aspirin / therapeutic use* Autoantibodies / blood Female Heparin / therapeutic use* Humans Immunotherapy Isoantibodies / blood Leukocytes, Mononuclear / immunology Male Platelet Aggregation Inhibitors / therapeutic use* Pregnancy Pregnancy Outcome Prospective Studies |
| Chemical | |
Reg. No./Substance:
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0/Anticoagulants; 0/Autoantibodies; 0/Isoantibodies; 0/Platelet Aggregation Inhibitors; 50-78-2/Aspirin; 9005-49-6/Heparin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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