| Heparin for patients with growth restricted fetus: a prospective randomized controlled trial. | |
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MedLine Citation:
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PMID: 19951008 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: Heparin was hypothesized to facilitate the growth of the growth-restricted fetus. Our study was to assess the efficiency of heparin in treating fetus with growth restriction and to explore the possible mechanisms. METHODS: Seventy-three pregnant women were selected in this study. Based on regular treatments, patients randomly received either heparin or dan-shen combined with low-molecular weight dextrose. A serial ultrasonography and hematological measurements were performed on each patient at the enrolment and 7 days after the first treatment. Neonatal birth weight, 1-min Apgar score and gestational age were recorded. Placentas were collected for apoptotic indices. RESULTS: Heparin significantly improved maternal hemorrheological indices, fetal growth velocities and neonatal outcomes. It also reduced apoptosis in trophoblasts. CONCLUSIONS: Our results provide evidence that heparin significantly improves the growth of the growth-restricted fetus. The growth improvement is probably achieved by the changes in maternal hemorrheology and the attenuated apoptosis in trophoblasts. |
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Authors:
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Yan-Hong Yu; Li-Yong Shen; Hua Zou; Zhi-Jian Wang; Shi-Peng Gong |
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Publication Detail:
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Type: Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians Volume: 23 ISSN: 1476-4954 ISO Abbreviation: J. Matern. Fetal. Neonatal. Med. Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-08-19 Completed Date: 2010-12-14 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101136916 Medline TA: J Matern Fetal Neonatal Med Country: England |
Other Details:
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Languages: eng Pagination: 980-7 Citation Subset: IM |
Affiliation:
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Department of Obstetrics and Gynecology, Nan Fang Hospital, Southern Medical University, Guangzhou 510515, People's Republic of China. yuyh20050712@hotmail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Anticoagulants / administration & dosage, therapeutic use Birth Weight / drug effects Female Fetal Development / drug effects Fetal Growth Retardation / drug therapy*, ultrasonography Glucose / administration & dosage, chemistry Heparin / administration & dosage, therapeutic use* Humans Molecular Weight Plant Preparations / administration & dosage Pregnancy Pregnancy Outcome Salvia miltiorrhiza / chemistry Ultrasonography, Prenatal Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Anticoagulants; 0/Plant Preparations; 50-99-7/Glucose; 9005-49-6/Heparin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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