Document Detail

Heparin: an old drug with a new paradigm.
MedLine Citation:
PMID:  386509     Owner:  NLM     Status:  MEDLINE    
Recent studies have shown that heparin is a biochemical representative of a distinct class of compounds known as linear anionic polyelectrolytes. Members of this class are mixtures of individual highly negatively charged chains that show a wide spectrum of specific reactions with biologically active proteins. Upon administration, heparin chains enter a cellular pool and effectively prevent thrombosis by increasing the electronegative potential of the vessel wall. Anticoagulant activity is an unusual feature of a few heparin chains and appears to play a minor role in many clinical uses and in physiological and pathological responses.
L B Jacques
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Science (New York, N.Y.)     Volume:  206     ISSN:  0036-8075     ISO Abbreviation:  Science     Publication Date:  1979 Nov 
Date Detail:
Created Date:  1979-12-20     Completed Date:  1979-12-20     Revised Date:  2007-03-19    
Medline Journal Info:
Nlm Unique ID:  0404511     Medline TA:  Science     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  528-33     Citation Subset:  IM    
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MeSH Terms
Antithrombin III / metabolism
Blood Coagulation / drug effects
Heparin / adverse effects,  pharmacology*,  therapeutic use
Mast Cells / physiology
Structure-Activity Relationship
Sulfates / metabolism
Thrombosis / prevention & control
Reg. No./Substance:
0/Ions; 0/Sulfates; 9000-94-6/Antithrombin III; 9005-49-6/Heparin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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