Document Detail

Heparin metabolism and heparin-release lipase activity during long-term estrogen-progestin treatment.
MedLine Citation:
PMID:  1250155     Owner:  NLM     Status:  MEDLINE    
Short-term oral contraceptive therapy has been reported to decrease postheparin lipolytic activity (PHLA). Resistance to heparin has been held responsible for this effect. To test several alternative explanations, we studied both PHLA and heparin concentrations in nine control women and nine women receiving long-term estrogen-progestin therapy after they were given heparin intravenously (10 units/kg). There were no significant differences in the concentration of heparin, its rate of disappearance, or calculated space of distribution between control and treated groups. PHLA was depressed (p less than 0.05) by approximately 50% during long-term estrongen-progestin therapy. PHLA disappearance was similar in both groups. Thus, reduced PHLA in women receiving long-term oral contraceptive therapy cannot be related to altered heparin metabolism or to accelerated enzyme disappearance from plasma. Long-term estrogen-progestin administration may decrease the heparin-facilitated release of individual triglyceride hydrolase activities or enhance the affinity of enzyme binding to tissues.
T J Ence; D E Wilson; C M Flowers; A L Chen; B W Glad; E J Hershgold
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Metabolism: clinical and experimental     Volume:  25     ISSN:  0026-0495     ISO Abbreviation:  Metab. Clin. Exp.     Publication Date:  1976 Feb 
Date Detail:
Created Date:  1976-04-10     Completed Date:  1976-04-10     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0375267     Medline TA:  Metabolism     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  139-45     Citation Subset:  IM    
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MeSH Terms
Contraceptives, Oral / pharmacology*
Depression, Chemical
Estradiol Congeners / pharmacology*
Ethinyl Estradiol / pharmacology
Heparin / diagnostic use,  metabolism*
Lipase / metabolism*
Mestranol / pharmacology
Norethindrone / pharmacology
Norethynodrel / pharmacology
Norgestrel / pharmacology
Progesterone Congeners / pharmacology*
Time Factors
Triglycerides / metabolism
Reg. No./Substance:
0/Contraceptives, Oral; 0/Estradiol Congeners; 0/Progesterone Congeners; 0/Triglycerides; 57-63-6/Ethinyl Estradiol; 6533-00-2/Norgestrel; 68-22-4/Norethindrone; 68-23-5/Norethynodrel; 72-33-3/Mestranol; 9005-49-6/Heparin; EC

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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