Document Detail


Heparin-mediated extracorporeal low density lipoprotein precipitation as a possible therapeutic approach in preeclampsia.
MedLine Citation:
PMID:  17081803     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Preeclampsia is a pregnancy-related hypertensive disease resulting in substantial maternal and neonatal morbidity and mortality. Until today there is no satisfactory treatment to stop disease progression except immediate delivery of the fetus. Heparin-mediated extracorporeal low density lipoprotein (LDL) precipitation (H.E.L.P.) apheresis removes simultaneously circulating LDL, lipoprotein(a) [Lp(a)], fibrinogen, C-reactive protein (CRP) and various proinflammatory and procoagulatory factors. This study was to test the feasibility of H.E.L.P. apheresis in preeclamptic patients and its potential effects on blood and placental markers of preeclampsia. We applied H.E.L.P. apheresis to nine preeclamptic patients and it was well tolerated. Their gestational ages could be continued by 17.7 (3-49) more days. Eight of the nine neonates did well during their neonatal stage. One infant died of late-onset sepsis. H.E.L.P. apheresis reduced significantly circulating levels of triglycerides, total and LDL-cholesterol, Lp(a), fibrinogen, hs-CRP, TNFalpha, sVCAM-1, E-selectin, lipopolysaccharide binding protein (LBP), homocysteine and plasma viscosity. We conclude that H.E.L.P. apheresis reduced maternal circulating levels of proinflammatory and coagulatory markers and plasma viscosity without overt maternal or neonatal clinical side effects.
Authors:
Ying Wang; Autar K Walli; Andreas Schulze; Frithjof Blessing; Peter Fraunberger; Christian Thaler; Dietrich Seidel; Uwe Hasbargen
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Publication Detail:
Type:  Clinical Trial; Journal Article     Date:  2006-11-01
Journal Detail:
Title:  Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis     Volume:  35     ISSN:  1473-0502     ISO Abbreviation:  Transfus. Apher. Sci.     Publication Date:  2006 Oct 
Date Detail:
Created Date:  2006-11-29     Completed Date:  2007-02-21     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  101095653     Medline TA:  Transfus Apher Sci     Country:  England    
Other Details:
Languages:  eng     Pagination:  103-10     Citation Subset:  T    
Affiliation:
Institute of Clinical Chemistry, University Hospital Grosshadern, Marchioninistrasse 15, 81377 Munich, Germany. cathy.wy@lrz.uni-muenchen.de
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MeSH Terms
Descriptor/Qualifier:
Blood Component Removal*
Blood Proteins / analysis
Chemical Precipitation
Female
Gestational Age
Heparin* / chemistry
Humans
Infant, Newborn
Inflammation Mediators / blood
Lipoproteins, LDL* / blood
Live Birth
Male
Pre-Eclampsia / blood,  therapy*
Pregnancy / blood
Chemical
Reg. No./Substance:
0/Blood Proteins; 0/Inflammation Mediators; 0/Lipoproteins, LDL; 9005-49-6/Heparin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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