Document Detail


Heparin and maternal fetal interface: why should it work to prevent pregnancy complications?
MedLine Citation:
PMID:  19716166     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Anticoagulant therapy has been used extensively for the prevention of recurrent pregnancy losses, and other placenta mediated complications, including prevention of preeclampsia and fetal growth restriction. While heparin anticoagulation is a standard treatment for antiphospholipid antibody syndrome, it is increasingly being used in the prevention of placenta mediated complications. In this article, we explore the role of heparin at maternal-fetal interface, the molecular mechanism of action for heparin, and ongoing basic and translational work being done to elucidate heparin's principal mechanisms of action.
Authors:
Nazli Hossain; Frederick Schatz; Michael J Paidas
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Publication Detail:
Type:  Journal Article; Review     Date:  2009-08-27
Journal Detail:
Title:  Thrombosis research     Volume:  124     ISSN:  1879-2472     ISO Abbreviation:  Thromb. Res.     Publication Date:  2009 Dec 
Date Detail:
Created Date:  2009-11-25     Completed Date:  2010-02-18     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0326377     Medline TA:  Thromb Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  653-5     Citation Subset:  IM    
Affiliation:
Department of Obstetrics & Gynecology Unit 3, Civil Hospital & Dow University of Health Sciences, Karachi, Pakistan. Nazli.hossain@duhs.edu.pk
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MeSH Terms
Descriptor/Qualifier:
Anticoagulants / therapeutic use
Complement System Proteins
Female
Fetal Death
Heparin / metabolism*
Humans
Maternal-Fetal Exchange
Placenta Diseases / prevention & control*
Pregnancy
Pregnancy Complications, Hematologic*
Pregnancy Outcome
Risk
Thrombophilia / complications,  immunology,  pathology
Chemical
Reg. No./Substance:
0/Anticoagulants; 9005-49-6/Heparin; 9007-36-7/Complement System Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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