Document Detail

Heparin and maternal fetal interface: why should it work to prevent pregnancy complications?
MedLine Citation:
PMID:  19716166     Owner:  NLM     Status:  MEDLINE    
Anticoagulant therapy has been used extensively for the prevention of recurrent pregnancy losses, and other placenta mediated complications, including prevention of preeclampsia and fetal growth restriction. While heparin anticoagulation is a standard treatment for antiphospholipid antibody syndrome, it is increasingly being used in the prevention of placenta mediated complications. In this article, we explore the role of heparin at maternal-fetal interface, the molecular mechanism of action for heparin, and ongoing basic and translational work being done to elucidate heparin's principal mechanisms of action.
Nazli Hossain; Frederick Schatz; Michael J Paidas
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Publication Detail:
Type:  Journal Article; Review     Date:  2009-08-27
Journal Detail:
Title:  Thrombosis research     Volume:  124     ISSN:  1879-2472     ISO Abbreviation:  Thromb. Res.     Publication Date:  2009 Dec 
Date Detail:
Created Date:  2009-11-25     Completed Date:  2010-02-18     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0326377     Medline TA:  Thromb Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  653-5     Citation Subset:  IM    
Department of Obstetrics & Gynecology Unit 3, Civil Hospital & Dow University of Health Sciences, Karachi, Pakistan.
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MeSH Terms
Anticoagulants / therapeutic use
Complement System Proteins
Fetal Death
Heparin / metabolism*
Maternal-Fetal Exchange
Placenta Diseases / prevention & control*
Pregnancy Complications, Hematologic*
Pregnancy Outcome
Thrombophilia / complications,  immunology,  pathology
Reg. No./Substance:
0/Anticoagulants; 9005-49-6/Heparin; 9007-36-7/Complement System Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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