| Heparin and maternal fetal interface: why should it work to prevent pregnancy complications? | |
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MedLine Citation:
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PMID: 19716166 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Anticoagulant therapy has been used extensively for the prevention of recurrent pregnancy losses, and other placenta mediated complications, including prevention of preeclampsia and fetal growth restriction. While heparin anticoagulation is a standard treatment for antiphospholipid antibody syndrome, it is increasingly being used in the prevention of placenta mediated complications. In this article, we explore the role of heparin at maternal-fetal interface, the molecular mechanism of action for heparin, and ongoing basic and translational work being done to elucidate heparin's principal mechanisms of action. |
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Authors:
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Nazli Hossain; Frederick Schatz; Michael J Paidas |
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Publication Detail:
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Type: Journal Article; Review Date: 2009-08-27 |
Journal Detail:
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Title: Thrombosis research Volume: 124 ISSN: 1879-2472 ISO Abbreviation: Thromb. Res. Publication Date: 2009 Dec |
Date Detail:
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Created Date: 2009-11-25 Completed Date: 2010-02-18 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0326377 Medline TA: Thromb Res Country: United States |
Other Details:
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Languages: eng Pagination: 653-5 Citation Subset: IM |
Affiliation:
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Department of Obstetrics & Gynecology Unit 3, Civil Hospital & Dow University of Health Sciences, Karachi, Pakistan. Nazli.hossain@duhs.edu.pk |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Anticoagulants
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therapeutic use Complement System Proteins Female Fetal Death Heparin / metabolism* Humans Maternal-Fetal Exchange Placenta Diseases / prevention & control* Pregnancy Pregnancy Complications, Hematologic* Pregnancy Outcome Risk Thrombophilia / complications, immunology, pathology |
| Chemical | |
Reg. No./Substance:
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0/Anticoagulants; 9005-49-6/Heparin; 9007-36-7/Complement System Proteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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