Document Detail

Heparin-induced thrombocytopenia and thrombosis: reversal with streptokinase. A case report and review of literature.
MedLine Citation:
PMID:  2012074     Owner:  NLM     Status:  MEDLINE    
Heparin-induced thrombocytopenia and thrombosis is associated with a significant incidence of morbidity and mortality. Prompt recognition of this complication and immediate withdrawal of heparin therapy are imperative. This report describes a case of heparin-induced thrombosis and thrombocytopenia with major vascular insufficiency of the extremities. This is the first reported instance of the use of intravenous streptokinase for the treatment of heparin-induced venous thrombosis.
D P Mehta; E L Yoder; J Appel; K L Bergsman
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Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  American journal of hematology     Volume:  36     ISSN:  0361-8609     ISO Abbreviation:  Am. J. Hematol.     Publication Date:  1991 Apr 
Date Detail:
Created Date:  1991-05-06     Completed Date:  1991-05-06     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  7610369     Medline TA:  Am J Hematol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  275-9     Citation Subset:  IM    
Department of Internal Medicine, Grace Hospital, Wayne State University School of Medicine, Detroit, Michigan.
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MeSH Terms
Heparin / adverse effects*
Injections, Intravenous
Streptokinase / administration & dosage,  therapeutic use*
Thrombocytopenia / chemically induced*,  drug therapy,  mortality
Thrombophlebitis / chemically induced*,  drug therapy,  mortality
Reg. No./Substance:
9005-49-6/Heparin; EC 3.4.-/Streptokinase

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