| Heparin-induced thrombocytopenia, thrombosis, and hemorrhage. | |
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MedLine Citation:
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PMID: 451885 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Twenty-two patients developed significant thrombocytopenia (5,000 to 96,000/cu mm; mean, 29,000/cu mm) while receiving prophylactic or therapeutic heparin. Seventeen of them developed serious thrombohemorrhagic complications which accelerated the deaths of six and contributed to the late death of one. Cessation of heparin therapy led to an immediate remission of the thrombohemorrhagic complications and thrombocytopenia, with no patient who was not already moribund dying, once appropriate therapy had been instituted. Platelet-count monitoring is recommended for all patients receiving heparin for more than 6 days, with cessation of heparin therapy mandatory for the successful management of patients with this disorder. Evidence is presented for an immunologic etiology for this disorder. |
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Authors:
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D N Kapsch; E H Adelstein; G R Rhodes; D Silver |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Surgery Volume: 86 ISSN: 0039-6060 ISO Abbreviation: Surgery Publication Date: 1979 Jul |
Date Detail:
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Created Date: 1979-09-01 Completed Date: 1979-09-01 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0417347 Medline TA: Surgery Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 148-55 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Blood Platelets Female Hematologic Tests Hemorrhage / chemically induced* Heparin / adverse effects*, therapeutic use Humans Male Middle Aged Thrombocytopenia / chemically induced* Thromboembolism / drug therapy Thrombosis / chemically induced* |
| Chemical | |
Reg. No./Substance:
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9005-49-6/Heparin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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