Document Detail

Heparin-induced thrombocytopenia in the presence of a heparin-bonded bypass graft.
MedLine Citation:
PMID:  22008977     Owner:  NLM     Status:  MEDLINE    
The use of prosthetic grafts in below-knee bypasses may be necessary in patients with no available autologous vein and critical limb ischemia not amenable to angioplasty. Such conduits, however, have generally yielded disappointing results. A new, heparin-bonded, expanded polytetrafluoroethylene graft (Gore Propaten vascular graft) designed to provide resistance to thrombosis may be associated with decreased early graft failure and increased patency. A concern with exposure to heparin, and therefore heparin-bonded prostheses, is the development of heparin-induced thrombocytopenia (HIT). Although rare, this requires prompt graft removal. We present a case to highlight this serious complication and review the literature on this topic.
M D Wheatcroft; E Greco; L Tse; G Roche-Nagle
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Publication Detail:
Type:  Case Reports; Journal Article     Date:  2011-10-18
Journal Detail:
Title:  Vascular     Volume:  19     ISSN:  1708-5381     ISO Abbreviation:  Vascular     Publication Date:  2011 Dec 
Date Detail:
Created Date:  2011-12-14     Completed Date:  2012-06-12     Revised Date:  2012-12-07    
Medline Journal Info:
Nlm Unique ID:  101196722     Medline TA:  Vascular     Country:  England    
Other Details:
Languages:  eng     Pagination:  338-41     Citation Subset:  IM    
Division of Vascular Surgery, Toronto General Hospital, Toronto, ON, Canada.
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MeSH Terms
Aged, 80 and over
Anticoagulants / adverse effects*
Blood Vessel Prosthesis*
Graft Occlusion, Vascular / drug therapy*
Heparin / adverse effects*
Peripheral Arterial Disease / surgery*
Thrombocytopenia / chemically induced*
Reg. No./Substance:
0/Anticoagulants; 9002-84-0/Polytetrafluoroethylene; 9005-49-6/Heparin
Comment In:
Vascular. 2012 Oct;20(5):299   [PMID:  22983542 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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