Document Detail

Heparin-induced thrombocytopenia and fatal thrombosis in a patient with activated protein C resistance.
MedLine Citation:
PMID:  7485105     Owner:  NLM     Status:  MEDLINE    
We report a 20-year-old woman who developed heparin-induced thrombocytopenia (HIT) associated with devastating and fatal multiorgan thrombosis. The patient, her mother, and her brother were found to have resistance to activated protein C (APC), and the congenital thrombophilia in this family was verified by the finding of the Arg506 Gln mutation in factor V. This is the first case of HIT and APC resistance. The consequences of this association are discussed.
J Gardyn; P Sorkin; Y Kluger; S Kabili; J M Klausner; A Zivelin; A Eldor
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  American journal of hematology     Volume:  50     ISSN:  0361-8609     ISO Abbreviation:  Am. J. Hematol.     Publication Date:  1995 Dec 
Date Detail:
Created Date:  1995-12-28     Completed Date:  1995-12-28     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7610369     Medline TA:  Am J Hematol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  292-5     Citation Subset:  IM    
Department of Medicine F and Surgery B, E. Souraski Tel-Aviv Medical Center, Israel.
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MeSH Terms
Base Sequence
DNA / chemistry
Drug Resistance
Factor V / genetics
Fatal Outcome
Heparin / adverse effects*
Mesenteric Arteries
Molecular Sequence Data
Protein C / pharmacology*
Thrombocytopenia / chemically induced*
Thrombosis / etiology*,  surgery
Reg. No./Substance:
0/Protein C; 9001-24-5/Factor V; 9005-49-6/Heparin; 9007-49-2/DNA

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