Document Detail

Heparin-induced spinal fractures.
MedLine Citation:
PMID:  439319     Owner:  NLM     Status:  MEDLINE    
A 27-year-old woman received heparin sodium for 152 days because of antepartum iliofemoral thrombophlebitis. At the end of this time, spinal osteoporosis and multiple vertebral fractures became clinically evident and were attributed to the prolonged administration of heparin. Previously reported cases of "heparin osteoporosis" were reviewed. The significance of the daily dose of heparin and the duration of therapy are reemphasized. This therapeutic complication and the management of antepartum iliofemoral thrombophlebitis are discussed. Prolonged administration of heparin in daily doses exceeding 10,000 units is potentially hazardous.
J W Squires; L W Pinch
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  JAMA     Volume:  241     ISSN:  0098-7484     ISO Abbreviation:  JAMA     Publication Date:  1979 Jun 
Date Detail:
Created Date:  1979-07-28     Completed Date:  1979-07-28     Revised Date:  2014-09-17    
Medline Journal Info:
Nlm Unique ID:  7501160     Medline TA:  JAMA     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  2417-8     Citation Subset:  AIM; IM    
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MeSH Terms
Fractures, Spontaneous / chemically induced*
Heparin / therapeutic use
Lumbar Vertebrae / injuries
Osteoporosis / chemically induced*
Pregnancy Complications, Cardiovascular*
Spinal Injuries / chemically induced*
Thoracic Vertebrae / injuries
Thrombophlebitis / drug therapy
Time Factors
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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