Document Detail


Heparin in the long-term management of ligneous conjunctivitis: a case report and review of literature.
MedLine Citation:
PMID:  21885957     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Ligneous conjunctivitis, secondary to inherited homozygous plasminogen deficiency, is a poorly understood condition that has the potential to hinder normal childhood development if not managed adequately. We report the clinical progression of a child with ligneous conjunctivitis, controlled with daily heparin eye drops, postsurgical excision, for a duration of approximately 5 years at a cost of approximately 30 USD per month. During this time, the patient's progress has been complicated by one occurrence of periorbital cellulitis and also otitis media. The patient has also experienced ocular complications due to the remaining membranous lesion. This case indicates that individual patient factors including plasminogen levels and exposure to triggers of ocular inflammation may influence the clinical progression of ligneous conjunctivitis. Furthermore, this study is one of the first to present over 5-year follow-up of a patient with ligneous conjunctivitis effectively managed with long-term heparin eye drops.
Authors:
Mandira Hiremath; James Elder; Fiona Newall; Susan Mitchell; Roxanne Dyas; Paul Monagle
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-8-31
Journal Detail:
Title:  Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis     Volume:  -     ISSN:  1473-5733     ISO Abbreviation:  -     Publication Date:  2011 Aug 
Date Detail:
Created Date:  2011-9-2     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9102551     Medline TA:  Blood Coagul Fibrinolysis     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
aDepartment of Clinical Haematology bDepartment of Ophthalmology cDepartment of Pharmacy, Royal Children's Hospital, Melbourne dDepartment of Paediatrics, University of Melbourne, Murdoch Children's Research Institute eHaematology Research, Murdoch Childrens Research Institute, Parkville, Victoria, Australia.
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