Document Detail


Heparin and heparan sulfate: structure and function.
MedLine Citation:
PMID:  12137280     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This review covers the structure and function of heparin and heparan sulfate glycosaminoglycans. Their chemical structures are discussed, including recently developed methods for sequencing picomole to nanomole quantities of heparin- and heparan sulfate-derived oligosaccharides. The biosynthesis of heparin and heparan sulfate is reviewed as it relates to their diverse and varied structures, and their biological activities and functions are discussed. The literature up to August 2001 is reviewed, and 208 references are cited.
Authors:
Dallas L Rabenstein
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Natural product reports     Volume:  19     ISSN:  0265-0568     ISO Abbreviation:  Nat Prod Rep     Publication Date:  2002 Jun 
Date Detail:
Created Date:  2002-07-24     Completed Date:  2002-09-17     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8502408     Medline TA:  Nat Prod Rep     Country:  England    
Other Details:
Languages:  eng     Pagination:  312-31     Citation Subset:  IM    
Affiliation:
Department of Chemistry, University of California, Riverside 92521, USA. dlrab@ucrac1.ucr.edu
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MeSH Terms
Descriptor/Qualifier:
Binding Sites
Blood Coagulation / drug effects
Carbohydrate Conformation
Carbohydrate Sequence
Disaccharides / chemistry
Glycosaminoglycans*
Growth Substances / metabolism
HIV-1 / physiology
Heparin*
Heparitin Sulfate*
Herpesvirus 1, Human / physiology
Lipase / metabolism
Lipoproteins / metabolism
Magnetic Resonance Spectroscopy
Mast Cells / chemistry
Molecular Sequence Data
Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
Grant Support
ID/Acronym/Agency:
HL56588/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Disaccharides; 0/Glycosaminoglycans; 0/Growth Substances; 0/Lipoproteins; 9005-49-6/Heparin; 9050-30-0/Heparitin Sulfate; EC 3.1.1.3/Lipase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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