Document Detail

Heparin elimination in patients with liver cirrhosis.
MedLine Citation:
PMID:  579516     Owner:  NLM     Status:  MEDLINE    
Heparin (100 U/kg body-weight) was injected intravenously, and heparin concentration in plasma determined by polybrene titration. Mean heparin half-life was 117.8 min in a group of patients with liver cirrhosis and normal renal function (n = 6) as compared to 74.0 min in the normal group (n = 6). The difference between the two groups is statistically significant (p approximately 0.02). Heparin half-life was correlated to galactose half-life in the patients (r=0.83, p= 0.05). The findings suggest that heparin is metabolized in the liver. There was a significant fall in antithrombin III activities in the normals, but not in the patients. A possible explanation may be that the normal liver removes heparin bound to antithrombin III, and that this function is impaired in liver cirrhosis.
A N Teien
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Thrombosis and haemostasis     Volume:  38     ISSN:  0340-6245     ISO Abbreviation:  Thromb. Haemost.     Publication Date:  1977 Oct 
Date Detail:
Created Date:  1978-02-18     Completed Date:  1978-02-18     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7608063     Medline TA:  Thromb Haemost     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  701-6     Citation Subset:  IM    
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MeSH Terms
Antithrombin III / metabolism
Antithrombins / blood
Galactose / metabolism
Heparin / metabolism*
Liver / metabolism
Liver Cirrhosis / blood,  metabolism*
Middle Aged
Reg. No./Substance:
0/Antithrombins; 26566-61-0/Galactose; 9000-94-6/Antithrombin III; 9005-49-6/Heparin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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