| Heparin elimination in patients with liver cirrhosis. | |
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MedLine Citation:
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PMID: 579516 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Heparin (100 U/kg body-weight) was injected intravenously, and heparin concentration in plasma determined by polybrene titration. Mean heparin half-life was 117.8 min in a group of patients with liver cirrhosis and normal renal function (n = 6) as compared to 74.0 min in the normal group (n = 6). The difference between the two groups is statistically significant (p approximately 0.02). Heparin half-life was correlated to galactose half-life in the patients (r=0.83, p= 0.05). The findings suggest that heparin is metabolized in the liver. There was a significant fall in antithrombin III activities in the normals, but not in the patients. A possible explanation may be that the normal liver removes heparin bound to antithrombin III, and that this function is impaired in liver cirrhosis. |
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Authors:
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A N Teien |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Thrombosis and haemostasis Volume: 38 ISSN: 0340-6245 ISO Abbreviation: Thromb. Haemost. Publication Date: 1977 Oct |
Date Detail:
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Created Date: 1978-02-18 Completed Date: 1978-02-18 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 7608063 Medline TA: Thromb Haemost Country: GERMANY, WEST |
Other Details:
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Languages: eng Pagination: 701-6 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Antithrombin III / metabolism Antithrombins / blood Female Galactose / metabolism Heparin / metabolism* Humans Liver / metabolism Liver Cirrhosis / blood, metabolism* Male Middle Aged |
| Chemical | |
Reg. No./Substance:
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0/Antithrombins; 26566-61-0/Galactose; 9000-94-6/Antithrombin III; 9005-49-6/Heparin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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