| Heparin effects on superoxide production by neutrophils. | |
| | |
MedLine Citation:
|
PMID: 7781656 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Heparin is widely used in the treatment of various diseases, but the mechanisms of its biologic actions remain largely obscure. Recently, oxygen radicals, which are produced in a variety of conditions and cause tissue damage, have been implicated in the pathophysiology of various diseases. To investigate the relationship between heparin and oxygen radical production by neutrophils, we compared the effects of standard heparin (heparin sodium), which has been widely used, and a recently developed low molecular weight heparin (LMWH) which has potent anti-Xa activity, on neutrophil oxygen radical production in vitro. Standard heparin increased neutrophil oxygen radical production slightly at the low concentrations used clinically but reduced it at high concentrations, so that the effect of heparin on neutrophil oxygen radical production was biphasic. The effects of LMWH on neutrophil oxygen radical production were slight at both low and high concentrations. In disseminated intravascular coagulation (DIC) locally activated neutrophils produce oxygen radicals and have toxic effects in vivo. Thus we concluded that LMWH should be indicated for the treatment of DIC. |
| | |
Authors:
|
K Itoh; A Nakao; W Kishimoto; H Takagi |
Related Documents
:
|
20553946 - Antithrombin and heparin cofactor ii-mediated inactivation of alpha-thrombin by a synth... 343096 - Purification and characterization of human and bovine platelet factor 4. 16113786 - Additive effects of anticoagulants: recombinant human activated protein c and heparin o... 11732526 - Increased pre-operative platelet counts are a possible predictor for reduced sensitivit... 21292776 - Deciphering the molecular and biologic processes that mediate histone deacetylase inhib... 8939186 - Effects of nedocromil sodium on airway neurogenic mechanisms. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: European surgical research. Europäische chirurgische Forschung. Recherches chirurgicales européennes Volume: 27 ISSN: 0014-312X ISO Abbreviation: Eur Surg Res Publication Date: 1995 |
Date Detail:
|
Created Date: 1995-07-14 Completed Date: 1995-07-14 Revised Date: 2006-11-30 |
Medline Journal Info:
|
Nlm Unique ID: 0174752 Medline TA: Eur Surg Res Country: SWITZERLAND |
Other Details:
|
Languages: eng Pagination: 184-8 Citation Subset: IM |
Affiliation:
|
Department of Surgery II, Nagoya University School of Medicine, Japan. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Chemiluminescent Measurements Free Radicals Heparin / pharmacology* Humans Neutrophils / drug effects*, metabolism Pyrazines / diagnostic use Superoxides / metabolism* |
| Chemical | |
Reg. No./Substance:
|
0/Free Radicals; 0/Pyrazines; 102146-00-9/2-methyl-6-phenyl-3,7-dihydroimidazo(1,2-a)pyrazin-3-one; 11062-77-4/Superoxides; 9005-49-6/Heparin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: The backflow from the pulmonary circulation for identification of the aortic origin of the bronchial...
Next Document: Effect of allogeneic polymorphonuclear neutrophils on staphylococcal sepsis in mice.