Document Detail

Heparin and antiaggregating therapy in unstable angina.
MedLine Citation:
PMID:  2083863     Owner:  NLM     Status:  MEDLINE    
Heparin and antiaggregating therapy represent an effective treatment of unstable angina. Aspirin is able to prevent myocardial infarction and death in patients with unstable angina, but is not able to control myocardial ischemia. On the contrary, heparin administered by continuous intravenous infusion (about 1,000 U/h) controls myocardial ischemia by very early lowering anginal attacks and silent ischemic episodes. Heparin intermittently administered (6,000 U i.v. four times daily) did not significantly affect anginal attacks and myocardial ischemia. Thrombolytic therapy alone (Alteplase 1.75 mg/kg) reduced, but not significantly, the number of anginal attacks. The reduction of myocardial ischemia induced by continuous infusion of heparin is associated with a decrease of fibrinopeptide A plasma levels, whereas the thromboxane B2 production by platelets seems to be irrelevant in order to obtain a reduction of myocardial ischemia. Thus thrombin formation seems to be a primary factor in the occurrence of refractory unstable angina and in the activation of platelets.
G G Neri Serneri; P A Modesti; R Abbate; G F Gensini
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Haemostasis     Volume:  20 Suppl 1     ISSN:  0301-0147     ISO Abbreviation:  Haemostasis     Publication Date:  1990  
Date Detail:
Created Date:  1991-05-16     Completed Date:  1991-05-16     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  0371574     Medline TA:  Haemostasis     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  113-21     Citation Subset:  IM    
1st Medical Clinic, University of Florence, Italy.
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MeSH Terms
Angina, Unstable / complications,  drug therapy*
Drug Therapy, Combination
Fibrinolytic Agents / therapeutic use
Heparin / therapeutic use*
Myocardial Infarction / etiology,  prevention & control
Platelet Activation / drug effects
Platelet Aggregation Inhibitors / therapeutic use*
Thrombin / biosynthesis
Reg. No./Substance:
0/Fibrinolytic Agents; 0/Platelet Aggregation Inhibitors; 9005-49-6/Heparin; EC

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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