| Heparin-Coated Colloidal Mesoporous Silica Nanoparticles Efficiently Bind to Antithrombin as an Anticoagulant Drug-Delivery System. | |
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MedLine Citation:
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PMID: 22161774 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Blood ties: We have designed a novel nanoscale, injectable drug-delivery system that combines heparin, which prevents blood clotting, with multifunctional core-shell colloidal mesoporous silica nanoparticles. The anticoagulant and biocompatible properties of heparin together with the highly porous features of the nanoparticles lead to an efficient multifunctional drug-delivery system that can itself act as an anticoagulant and allows for incorporation of biologically active molecules as deliverable cargo. |
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Authors:
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Christian Argyo; Valentina Cauda; Hanna Engelke; Joachim Rädler; Gregor Bein; Thomas Bein |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-12-12 |
Journal Detail:
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Title: Chemistry (Weinheim an der Bergstrasse, Germany) Volume: - ISSN: 1521-3765 ISO Abbreviation: - Publication Date: 2011 Dec |
Date Detail:
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Created Date: 2011-12-13 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9513783 Medline TA: Chemistry Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. |
Affiliation:
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Department of Chemistry and Center for NanoScience (CeNS), University of Munich (LMU), Butenandtstraße 5-13, Gerhardt-Ertl-Building, 81377 München (Germany), Fax: (+49) 89-2180-77622, Dr. V. Cauda, present address: Italian Institute of Technology, CSHR@Polito, C. so Trento 21, 10129 Turin (Italy) http://bein.cup.uni-muenchen.de. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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