Document Detail


Heparin-Coated Colloidal Mesoporous Silica Nanoparticles Efficiently Bind to Antithrombin as an Anticoagulant Drug-Delivery System.
MedLine Citation:
PMID:  22161774     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Blood ties: We have designed a novel nanoscale, injectable drug-delivery system that combines heparin, which prevents blood clotting, with multifunctional core-shell colloidal mesoporous silica nanoparticles. The anticoagulant and biocompatible properties of heparin together with the highly porous features of the nanoparticles lead to an efficient multifunctional drug-delivery system that can itself act as an anticoagulant and allows for incorporation of biologically active molecules as deliverable cargo.
Authors:
Christian Argyo; Valentina Cauda; Hanna Engelke; Joachim Rädler; Gregor Bein; Thomas Bein
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-12-12
Journal Detail:
Title:  Chemistry (Weinheim an der Bergstrasse, Germany)     Volume:  -     ISSN:  1521-3765     ISO Abbreviation:  -     Publication Date:  2011 Dec 
Date Detail:
Created Date:  2011-12-13     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9513783     Medline TA:  Chemistry     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Affiliation:
Department of Chemistry and Center for NanoScience (CeNS), University of Munich (LMU), Butenandtstraße 5-13, Gerhardt-Ertl-Building, 81377 München (Germany), Fax: (+49) 89-2180-77622, Dr. V. Cauda, present address: Italian Institute of Technology, CSHR@Polito, C. so Trento 21, 10129 Turin (Italy) http://bein.cup.uni-muenchen.de.
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